Evidence map›Paper›PMID 40110067›Full record

ReviewNeuro-oncology practice2025

Brain tumors and fitness to drive: A review and multi-disciplinary approach.

Mark Willy L Mondia, Edward K Avila, Jeffrey S Wefel, Rachel F Hehn, Alex R Bowers, Brian S Cox, Daniel J Cox, David Schiff

Abstract readReview
In one paragraph

Review in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark Willy L MondiaDivision of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-8862-5360
Edward K AvilaDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-8489-2090
Jeffrey S WefelSection of Neuropsychology, Departments of Neuro-Oncology and Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Rachel F HehnTherapy Services, Penn State Health, Hershey, Pennsylvania, USA.
Alex R BowersDepartment of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6038-0178
Brian S CoxAlabama Research Institute of Aging, University of Alabama, Tuscaloosa, Alabama, USA.
Daniel J CoxVirginia Driving Safety Laboratory, Departments of Psychiatry and Neurobehavioral Sciences, Ophthalmology, University of Virginia, Charlottesville, Virginia, USA.
David SchiffDivision of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-1896-2502

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background: Patients with brain tumors and their families often inquire about driving safety. Currently, there is no consensus regarding fitness-to-drive (FTD) for patients with central nervous system tumors. Our paper aims to provide a multi-disciplinary perspective to address this issue. Methods: We performed a literature review for brain tumors and driving. Additionally, we solicited input from experts in tumor-related epilepsy, ophthalmology, neuropsychology, occupational therapy, and driving simulators. Results: We qualitatively analyzed 14 published articles. FTD determination varies internationally and regionally in most developed nations. Significant motor weakness and major cognitive impairment clearly prevent patients from driving. There are specialized tests for motor, vision, and cognitive correlates important to driving, but driving simulators and on-the-road tests provide the most comprehensive assessments. FTD for patients with seizures is dependent on region-specific laws that take into account the duration of seizure-free intervals and history of motor vehicular crashes. Conclusions: We recommend a symptom-based approach that highlights the importance of interdisciplinary assessment to ensure that brain tumor patients have the minimum operational skills required to drive. It is crucial to document seizure control, visual acuity impairment, and visual field deficits because these factors usually become the default basis in practice to determine if driving privileges can be maintained. Appropriately, timed assessment of cognitive function may provide pertinent information to determine FTD. Formalized testing with practical driving evaluation may eventually be necessary in patients who have hemiparesis, hemiplegia, hemineglect, homonymous visual field loss, or any form of cognitive dysfunction to determine FTD.

Indexed as

brain tumorsdrivingfitness-to-driveneuro-oncology

Identifiers

PMID40110067
PMCPMC11913653

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.