ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Using remote, digital, multi-day testing to characterize long-term forgetting in cognitively unimpaired older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- The myth of digital biomarkers in Alzheimer's disease: how to make them a reality.Current opinion in psychiatry · 2026Review
- Real-world evidence from 50,000 online participants using MoCA-XpressO for cognitive prescreening.Scientific reports · 2026Article
- Identifying early changes in imaging, plasma, and digital cognitive biomarkers that correspond to Alzheimer's disease pathology in the presence of autopsy-confirmed co-pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Using remote, digital, multi-day testing to characterize long-term forgetting in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
introductionAccelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.
methodsOne hundred four cognitively unimpaired older adults completed a face-name memory task for seven consecutive days and were asked to recognize face-name pairs 1 week later. LTF was computed as the number of correctly identified stimuli divided by a participant's maximum performance during learning.
resultsBetter learning was associated with less LTF (β = 0.52, 95% confidence interval [CI]:0.34-0.71, p < 0.001). Accelerated LTF was associated with cortical thinning in AD-signature regions (β = 0.33, 95% CI: 0.13-0.52, p = 0.001), but associations with regional tau were more subtle. DISCUSSION: Remote, multi-day testing may facilitate the assessment of LTF as an early cognitive marker of preclinical AD, but further replication is needed. HIGHLIGHTS: Using digital, remote assessments, we evaluated long-term forgetting in cognitively unimpaired older adults. We found a potential association between long-term forgetting and tau in Alzheimer's disease (AD)-related regions. Assessing long-term forgetting may facilitate early detection of AD-related cognitive decline.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.