Evidence map›Paper›PMID 40110717›Full record

ArticleJournal of cell science2025

Select autosomal dominant DFNA11 deafness variants activate Myo7A targeting in epithelial cells.

Prashun Acharya, Garima Thapa, Xiayi Liao, Samaneh Matoo, Maura J Graves, Sarah Y Atallah, Ashna K Tipirneni, Tram Nguyen, Niki M Chhabra, Jaden Maschack and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Prashun AcharyaDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Garima ThapaDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Xiayi LiaoDepartment of Biology, Indiana University, Indianapolis, IN 46202, USA.
Samaneh MatooDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Maura J GravesDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Sarah Y AtallahDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Ashna K TipirneniDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Tram NguyenDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Niki M ChhabraDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Jaden MaschackDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Mackenzie R HerodDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Favour A OhaezuDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Alder RobisonDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Ashwini MudaliyarDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Jasvinder BharajDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Nicole RoeserDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Katherine HolmesDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Vishwaas NayakDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Rayah AlsayedDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.
Benjamin J PerrinDepartment of Biology, Indiana University, Indianapolis, IN 46202, USA.
Scott W CrawleyDepartment of Biological Sciences, University of Toledo, Toledo, OH 43606, USA.ORCID 0000-0001-7808-9277

Funding

Cytoskeletal stability in stereocilia maintenanceR01DC015495 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI BENJAMIN J PERRIN · 2017 to 2026
$3.9M
CDHR5 tumor suppressor function in the intestineR15CA264735 · NCI · UNIVERSITY OF TOLEDO · PI CRAWLEY, WILLIAM SCOTT · 2021 to 2021
$449k
Molecular basis of apical protrusion organization and function in specialized epitheliaR15GM131382 · NIGMS · UNIVERSITY OF TOLEDO · PI CRAWLEY, WILLIAM SCOTT · 2018 to 2018
$449k
NCI NIH HHS R15 CA264735NIDCD NIH HHS R01 DC015495NIGMS NIH HHS R15 GM131382NIH HHS R01DC015495Northern Ohio Alliances for Graduate Education and the ProfessoriateUniversity of Toledo
6 · The paper itself

Abstract

Myosin-7A (Myo7A) is a motor protein crucial for the organization and function of stereocilia, specialized actin-rich protrusions on the surface of inner ear hair cells that mediate hearing. Variants in Myo7A cause several forms of genetic hearing loss, including autosomal dominant DFNA11 deafness. Despite its importance, the structural elements that control Myo7A within cells are not well understood. In this study, we used cultured kidney epithelial cells to screen for mutations that activate the motor-dependent targeting of Myo7A to the tips of apical microvilli on these cells. Our findings reveal that the targeting of Myo7A is regulated by specific IQ motifs within its lever arm and that this regulation can function at least partially independent of its tail sequence. Importantly, we demonstrate that many of the DFNA11 deafness variants reported in patients activate Myo7A targeting, providing a potential explanation for the autosomal dominant genetics of this form of deafness.

Indexed as

DeafnessEpithelial CellsMyosinsAnimalsGenes, DominantHumansMutationMyosin VIIaMYO7A protein, humanMyosinsMyosin VIIaActinBrush borderDeafnessEpitheliaLight chainsMicrovilliMyosinStereocilia

Identifiers

PMID40110717
PMCPMC12045598

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.