Evidence map›Paper›PMID 40110855›Full record

ArticleJournal of medicinal chemistry2025

Chemoproteomic Profiling of

David J Shirley, Meganathan Nandakumar, Aurora Cabrera, Bonnie Yiu, Emily Puumala, Zhongle Liu, Nicole Robbins, Luke Whitesell, Jeffrey L Smith, Scott Lyons and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

David J ShirleyStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0009-0003-2475-7366
Meganathan NandakumarStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-9093-2244
Aurora CabreraDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Bonnie YiuDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
Emily PuumalaDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
Zhongle LiuDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
Luke WhitesellDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
Jeffrey L SmithStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Scott LyonsDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Angie L MordantDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Laura E HerringDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-4496-7312
Lee M GravesDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-4736-9855
Rafael M CouñagoStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-1847-5090
David H DrewryStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0001-5973-5798
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-5797-0110
Timothy M WillsonStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-4181-8223

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesisR01AI162789 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen, Timothy M Willson · 2022 to 2026
$3.1M
Elucidating the mechanism of action of novel ClpP activators in activation of the mitochondrial unfolded protein response.R01GM138520 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRAVES, LEE M · 2020 to 2023
$1.3M
Request for a 500 MHz NMR console and nitrogen-cooled cryoprobeS10OD032476 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, ANDREW L · 2022 to 2022
$599k
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI162789NIGMS NIH HHS R01 GM138520NIH HHS S10 OD032476
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antifungal AgentsCandida albicansCasein Kinase IFungal ProteinsProtein Kinase InhibitorsProteomicsHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAntifungal AgentsCasein Kinase IFungal ProteinsProtein Kinase Inhibitors

Identifiers

PMID40110855
PMCPMC11997987

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.