Trial reportOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025
Estimation of Minimal Clinically Important Difference for Tinnitus Handicap Inventory and Tinnitus Functional Index.
Trial report in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Notch-induced lateral inhibition compared to standard amplification lateral inhibition therapy for the treatment of chronic tinnitus: A randomised controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Trial
- Efficacy of donepezil in patients with chronic tinnitus.Clinics (Sao Paulo, Brazil) · 2026Article
- Uncovering latent trajectories of daily tinnitus symptoms through app-based monitoring during treatment.Internet interventions · 2026Article
- Study protocol for a randomized controlled trial comparing penetrating needling and cognitive behavioral therapy for subjective tinnitus.Frontiers in neurology · 2026Article
- Article
- Enriched Acoustic Environment Therapy (EAE): A Cost-Effective and Feasible Alternative to Tinnitus Retraining Therapy (TRT).Healthcare (Basel, Switzerland) · 2025Article
- Impact of Hearing Aid Amplification on Subjective Tonal Tinnitus in Patients with Gently Sloping and Ski-Slope Hearing Loss: A Retrospective Cohort Study.Audiology research · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe minimal clinically important difference (MCID) represents the smallest change in treatment outcome deemed clinically meaningful. This study estimates the MCID for 2 widely used tinnitus measures: the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI), using anchor-based approaches while accounting for baseline severity and time interval. STUDY
designA multi-center randomized clinical trial.
settingEuropean tinnitus centers.
methodsAnchor-based approaches, including the effect size, receiver-operating characteristics, and ΔTHI/TFI methods, were employed to determine the MCID. The "minimally improved" category of the Clinical Global Impression Scale-Improvement (CGI-I) served as the anchor. The standard error of measurement was used to assess random variation.
resultsFor the THI, MCID estimates ranged from 7.8 to 12, with a point estimate of 11 after 12 weeks of treatment (N = 364). For the TFI, MCID estimates ranged from 7.3 to 9.4, with a point estimate of 9 points after 12 weeks (N = 359). Both measures indicated that higher baseline severity and longer time intervals required greater score reduction for clinical relevance.
conclusionThis study highlights the context-specific nature of MCID values for tinnitus measures and emphasizes the need for consensus on optimal anchor-based approaches to improve comparability.
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