ArticleExperimental physiology2025
Limited matching of the cardiac output response to the peripheral demand of heat stress and exercise.
Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Estimated exercise-induced maximal myocardial blood flow in untrained and endurance-trained men.Experimental physiology · 2026Article
- The diagnostic value of multimodal imaging for myocardial injury in heat stroke.Frontiers in cardiovascular medicine · 2026Article
- Limited matching of the cardiac output response to the peripheral demand of heat stress and exercise.Experimental physiology · 2025Article
- The unspecific control of cardiac output during exercise and in (patho-)physiology: Time to get more specific!Experimental physiology · 2025Article
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Authors and funding
9 authors.
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Abstract
It is widely accepted that cardiac output matches the prevailing peripheral demand in healthy humans. However, it remains unknown whether stroke volume and heart rate are regulated interdependently to arrive at a specific cardiac output. The aim of this study was to determine whether the healthy human heart responds specifically according to the peripheral demands of heat stress and exercise. Eleven healthy humans (women/men n = 3/8; age = 26 ± 2 years; body mass = 73 ± 11 kg) underwent leg heat stress and cycling exercise (60 W), with and without blood flow restriction (pressure set at the prevailing mean arterial pressure of the individual). Cardiac output was measured with triplane echocardiography. Additionally, haemodynamics, oxygen consumption, carbon dioxide production and lactate were assessed. Data were analysed using two-way repeated-measures ANOVA. Despite stable heat and exercise demands, cardiac output decreased significantly with blood flow restriction in both conditions (Δ-0.87 and -1.03 L min
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