Evidence map›Paper›PMID 40111577›Full record

ArticleJournal of neuro-oncology2025

Days at home after treatment of spinal metastases: measurement and validation of a novel patient centered outcome.

Husain Shakil, Armaan K Malhotra, Ahmad Essa, Vishwathsen Karthikeyan, Christopher S Lozano, Yingshi He, Jetan H Badhiwala, Arjun Sahgal, Nicolas Dea, Michael G Fehlings and 4 more

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Husain ShakilDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada. Husain.Shakil@medportal.ca.
Armaan K MalhotraDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Ahmad EssaLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Vishwathsen KarthikeyanDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Christopher S LozanoDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Yingshi HeLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Jetan H BadhiwalaDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Nicolas DeaNeurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
Michael G FehlingsDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Alexander KissInstitute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Christopher D WitiwDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Jefferson R WilsonDivision of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, 149 College Street, 5th Floor Stewart Building, Toronto, ON, M5T1P5, Canada.
Donald A RedelmeierInstitute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Funding

CIHR FBD-189794
6 · The paper itself

Abstract

purposeClinically meaningful population health outcomes for patients with spinal metastases are lacking. This study quantifies and validates days at home (DAH) after treatment of spinal metastases, and investigates factors associated with this patient-centered outcome.

methodsA population-based cohort study was conducted with the 2007-2019 Ontario Cancer Registry. Patients aged over 18 years undergoing surgery and/or radiation for a spinal metastasis were included. DAH was assessed at 3 months, 6 months (DAH-180), 1 year (DAH-365), and 2 years (DAH-730) after first treatment. Associations between DAH and primary cancer type, age, and frailty were assessed using multivariable quantile regression to estimate adjusted medians differences (aMD) in DAH. Predictive validity was determined with Spearman correlations between DAH-180 and longer-term DAH measures.

resultsWe identified 36,233 treated patients. Median DAH for patients after 3 months, 6 months, 1 year, and 2 years from treatment were 79 days, 114 days, 120 days, and 121 days, respectively. Lower home time was associated with older age (aMD: -16 days per decade increase in age), and frailty (aMD: -36). Primary cancers associated with the least DAH included gastrointestinal cancer (aMD: -162 days), lung cancer (aMD: -165 days), and melanoma (aMD: -167 days). DAH-180 demonstrated predictive validity with longer term DAH-365 (p < 0.001), and DAH-730 (p < 0.001).

conclusionThese data help validate DAH as a reliable metric for patients treated for spinal metastases. Patients with older age, frailty, high health resource utilization, and primary melanoma, gastrointestinal or lung cancer were found to have the fewest DAH after treatment.

Indexed as

Spinal NeoplasmsAdultAgedAged, 80 and overCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRegistriesCohort studiesDays at homeEpidemiologyHome timePatient-Centered outcome measuresSpinal metastasis

Identifiers

PMID40111577

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.