Evidence map›Paper›PMID 40111694›Full record

ArticleAdvances in experimental medicine and biology2025

The Oral Microbiome in Diabetes, Arterial Hypertension, and Obesity: A Scoping Review.

Camilla Pedrosa Vieira Lima, Patrícia Pauletto, Renata Maria Lataro, Graziela De Luca Canto, Naile Dame-Teixeira, Cristine Miron Stefani

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camilla Pedrosa Vieira LimaUniversity of Brasília, Brasília, Brazil.
Patrícia PaulettoUniversidad De las Americas - UDLA, Quito, Ecuador.
Renata Maria LataroFederal University of Santa Catarina - UFSC, Florianopolis, Brazil.
Graziela De Luca CantoFederal University of Santa Catarina - UFSC, Florianopolis, Brazil.
Naile Dame-TeixeiraUniversity of Brasília, Brasília, Brazil.
Cristine Miron StefaniUniversity of Brasília, Brasília, Brazil. cmstefani@unb.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChanges in the oral microbiome are expected in the presence of chronic conditions such as type 2 diabetes mellitus (T2D), arterial hypertension (AH), and obesity (OB).

objectiveWe aimed to map the literature regarding oral microbiome changes in people with T2D, AH, or OB compared to those without these conditions.

methodsThis scoping review was guided by the JBI Manual for Evidence Synthesis and reported according to the PRISMA extension for scoping reviews (PRISMA-ScR). A search strategy was developed and adapted to five databases (Embase, LILACS, PubMed, Scopus, and Web of Science) and gray literature (Google Scholar and ProQuest Dissertation and Thesis). Two reviewers individually screened studies for inclusion. Data from the studies, including the molecular method to evaluate the microbiome and the type of sample, were extracted and analyzed. The focus was significant changes in phylum and genera.

resultsA total of 1413 records were retrieved from databases, 86 from gray literature, and 7 from reference lists. After the screening process, 50 records were included, 28 on T2D, 8 on AH, and 12 on OB. Two studies addressed metabolic syndromes. Most studies identified the oral microbiome in saliva using 16S rRNA amplicon sequencing.

conclusionAt the phylum level, Fusobacteria was enriched in ≥3 studies in people with T2D. Firmicutes enrichment was associated with T2D and OB. Genera enriched in T2D comprised Catonella, Leptotrichia, Prevotella, and Rothia. Aggregatibacter and Prevotella were enriched in OB. No phylum or genera were consistently enriched in AH.OSF protocol registration: DOI 10.17605/OSF.IO/XK72V (available at https://osf.io/z5fp4 ).

Indexed as

Diabetes Mellitus, Type 2HypertensionMicrobiotaMouthObesityBacteriaHumansArterial hypertensionDiabetes mellitusDysbiosisObesityOral microbiomeOverweightScoping review

Identifiers

PMID40111694

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.