Evidence map›Paper›PMID 40112084›Full record

ArticleJournal of the National Cancer Institute2025

Associations of self-identified race and ethnicity and genetic ancestry with mortality among cancer survivors.

Jacqueline B Vo, Derek W Brown, Ian D Buller, Jaimie Z Shing, Naoise Synnott, Rena R Jones, Maria Teresa Landi, Wen-Yi Huang, Mitchell J Machiela, Amy Berrington de González and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacqueline B VoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-8891-4437
Derek W BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-8393-1713
Ian D BullerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-9477-8582
Jaimie Z ShingDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-7064-4424
Naoise SynnottDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-8331-1143
Rena R JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0003-1294-1679
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0003-4507-329X
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-4440-3368
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-6538-9705
Amy Berrington de GonzálezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-7332-8387
Timiya S NolanO'Neal Comprehensive Cancer Center, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.ORCID 0000-0002-6700-3105
Peter KraftDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-4472-8103
Faustine WilliamsDivision of Intramural Research, National Institute on Minority Health and Health Disparities, Bethesda, MD, United States.ORCID 0000-0002-7960-2463
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.ORCID 0000-0003-0074-1098

Funding

14th Annual American Association for Cancer Research ConferenceEthnic Minorities and the Medically UnderservedMinority Health and Health Disparities Research InnovationNCI NIH HHSNIH HHSNIMHD NIH HHSScience of Cancer Health Disparities in Racial
6 · The paper itself

Abstract

Self-identified race and ethnicity (SIRE) and genetic ancestry are potentially associated with disparities in health outcomes; however, independent effects of SIRE and genetic ancestry on mortality in cancer survivors including when adjusting for multiple risk factors are understudied. Among 23 445 cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Screening Trial, SIRE was associated with mortality among prostate, colorectal, lung, ovarian, and breast cancer survivors; genetic ancestry was associated with mortality among prostate, colorectal, and breast cancer survivors. Associations were strong when adjusting for age at cancer diagnosis, sex, and tumor characteristics but attenuated when adjusting for individual-level factors and population-level socioeconomic status. For example, mortality risk was higher among Black vs White prostate cancer survivors and African genetic ancestry vs European genetic ancestry, but associations were attenuated after multilevel adjustment. Results suggest that SIRE and genetic ancestry do not solely reflect biologic variation; rather, social factors may drive mortality differences by SIRE and genetic ancestry.

Indexed as

Cancer SurvivorsNeoplasmsRacial GroupsAgedBlack or African AmericanBreast NeoplasmsFemaleHealth Status DisparitiesHispanic or LatinoHumansMaleMiddle AgedProstatic NeoplasmsRisk Factors

Identifiers

PMID40112084
PMCPMC12597501

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.