Evidence map›Paper›PMID 40112155›Full record

ArticleMolecular pharmaceutics2025

Computational Approaches for Predicting Drug Interactions with Human Organic Anion Transporter 4 (OAT4).

Lucy Martinez-Guerrero, Patricia A Vignaux, Joshua S Harris, Thomas R Lane, Fabio Urbina, Stephen H Wright, Sean Ekins, Nathan J Cherrington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucy Martinez-GuerreroDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel, Tucson, Arizona 85721, United States.ORCID 0000-0002-7509-4684
Patricia A VignauxCollaborations Pharmaceuticals, Inc., 840 Main Campus Dr., Raleigh, North Carolina 27606, United States.ORCID 0009-0004-4015-6410
Joshua S HarrisCollaborations Pharmaceuticals, Inc., 840 Main Campus Dr., Raleigh, North Carolina 27606, United States.
Thomas R LaneCollaborations Pharmaceuticals, Inc., 840 Main Campus Dr., Raleigh, North Carolina 27606, United States.ORCID 0000-0001-9240-4763
Fabio UrbinaCollaborations Pharmaceuticals, Inc., 840 Main Campus Dr., Raleigh, North Carolina 27606, United States.
Stephen H WrightDepartment of Physiology, College of Medicine, University of Arizona, 1200 E. University Blvd., Tucson, Arizona 85724, United States.
Sean EkinsCollaborations Pharmaceuticals, Inc., 840 Main Campus Dr., Raleigh, North Carolina 27606, United States.ORCID 0000-0002-5691-5790
Nathan J CherringtonDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel, Tucson, Arizona 85721, United States.

Funding

MegaTrans – human transporter machine learning modelsR42GM131433 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI CHERRINGTON, NATHAN J, EKINS, SEAN · 2022 to 2023
$1.7M
NIGMS NIH HHS R42 GM131433
6 · The paper itself

Abstract

Human Organic Anion Transporter 4 (OAT4) is predominantly expressed in the kidneys, particularly in the apical membrane of the proximal tubule cells. This transporter is involved in the renal handling of endogenous and exogenous organic anions (OAs), making it an important transporter for drug-drug interactions (DDIs). To better understand OAT4-compound interactions, we generated single concentration (25 μM)

Indexed as

Organic Anion Transporters, Sodium-IndependentAnimalsCHO CellsCricetulusDrug InteractionsEstroneFluoresceinsHumansOchratoxinsOrganic Anion Transport Protein 16-carboxyfluoresceinEstroneestrone sulfateFluoresceinsochratoxin AOchratoxinsOrganic Anion Transporters, Sodium-IndependentOrganic Anion Transport Protein 1SLC22A6 protein, humanConformal PredictorsDrug−Drug Interactions (DDIs)Drug ScreeningHuman Organic Anion Transporter 4 (OAT4)Machine LearningMegaTransOrganic Anions (OAs)Predictive Modeling

Identifiers

PMID40112155
PMCPMC12150280

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.