Evidence map›Paper›PMID 40114038›Full record

Trial reportEuropean journal of clinical nutrition2025

Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D

Peng Ni, Ze Xu, Yujing Zhang, Dongdong Zhang, Hongwei Wen, Yaping Liu, Wenjie Li, Xing Li

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng Ni *Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Ze Xu *Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Yujing Zhang *Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.ORCID http://orcid.org/0000-0002-5207-1762
Dongdong ZhangDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Hongwei WenDepartment of Public Health, Zhengzhou Shuqing Medical College, Zhengzhou, Henan, China.
Yaping LiuDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Wenjie LiDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. lwj@zzu.edu.cn.
Xing LiDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. lixing530@zzu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81872626National Natural Science Foundation of China (National Science Foundation of China) 82003454National Natural Science Foundation of China (National Science Foundation of China) 82173515
6 · The paper itself

Abstract

backgroundPrediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D

methodsA total of 240 prediabetic participants received orally 1600 IU of vitamin D

resultsCYP2R1 rs12794714 AA carriers had less increased 25(OH)D

conclusionsThe results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D

Indexed as

CholecalciferolCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2Dietary SupplementsPolymorphism, Single NucleotidePrediabetic StateAdultAgedFemaleHumansMaleMiddle AgedVitamin D-Binding ProteinCholecalciferolCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2GC protein, humanVitamin D-Binding Protein

Identifiers

PMID40114038

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.