Evidence map›Paper›PMID 40114674›Full record

ArticleFrontiers in allergy2025

Case Report: Eosinophilic esophagitis and hen's egg tolerance-two cases, treated with topical steroids, showing remission with highly heated but not less heated hen's egg.

Lisa Nuyttens, Liselot De Vlieger, Toon Ieven, Marianne Diels, Tessa Bosmans, Sara Van Meerbeeck, Tine Alliet, Toon Dominicus, Ilse Hoffman, Dominique M A Bullens

Abstract readCase Reports
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa NuyttensAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology & Transplantation, KU Leuven, Leuven, Belgium.
Liselot De VliegerAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology & Transplantation, KU Leuven, Leuven, Belgium.
Toon IevenAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology & Transplantation, KU Leuven, Leuven, Belgium.
Marianne DielsDepartment of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
Tessa BosmansPediatric Gastroenterology, Hepatology and Nutrition, University Hospitals Leuven, Leuven, Belgium.
Sara Van MeerbeeckPediatric Gastroenterology, Hepatology and Nutrition, University Hospitals Leuven, Leuven, Belgium.
Tine AllietDepartment of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
Toon DominicusDepartment of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
Ilse HoffmanPediatric Gastroenterology, Hepatology and Nutrition, University Hospitals Leuven, Leuven, Belgium.
Dominique M A BullensAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology & Transplantation, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) is a chronic, antigen-mediated disease characterized by eosinophilic inflammation of the esophagus. Common triggers in Europe include cow's milk, hen's egg, wheat, soy, (pea)nuts, and (shell)fish. Recent studies indicate that heated forms of cow's milk in cow's milk-induced EoE may be well tolerated. Similar to cow's milk, we present two cases of children with hen's egg-triggered pediatric EoE treated with topical steroids who remained in remission after the introduction of highly heated forms of hen's egg. The introduction of less heated forms, however, led to relapse. These two cases suggest that heated hen's egg may be well tolerated in hen's egg-induced pediatric EoE, potentially allowing for a less restrictive diet and improved quality of life. Further research is necessary to explore the potential for inducing tolerance to less heated and/or raw egg through the gradual introduction of heated egg products.

Indexed as

case reportheated hen’s egghen’s egg-triggered EoEPedEoEtolerance

Identifiers

PMID40114674
PMCPMC11924201

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.