ArticleFrontiers in immunology2025
Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Performance of time-lapsed turbidimetry and agar plating as bacterial quantification methods.Microbiology spectrum · 2026Article
- The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response.Nature communications · 2025Article
- Integrative RNA-seq analysis reveals immune-related hub genesInternational journal of reproductive biomedicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Introduction: Bacterial pneumonia is a burdensome, costly disease and increasingly challenging to treat due to antibiotic resistance. Complex host-pathogen interactions regulate protective immunity. Neutrophils play a central role in pulmonary bacterial immunity, and mechanistic understanding of neutrophil functions in bacterial pneumonia has potential clinical and fundamental application. Nuclear receptor 4a1 (Nr4a1), a member of the nuclear orphan receptor family, has been described to regulate inflammation and immune development in a cell type-specific manner, but its role in pulmonary host defense is not well understood. Methods: Wild-type (WT) and Results: Nr4a1-deficient mice are highly susceptible to Klebsiella pneumoniae pneumonia, which was mediated by Discussion: Neutrophil
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.