Evidence map›Paper›PMID 40115028›Full record

ArticleiScience2025

Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer's mouse model.

Luyan Zhang, Letizia Santoni, Nam Anh Ngo, Reyila Simayi, Eleonora Ficiará, Luisa de Vivo, Michele Bellesi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luyan ZhangSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Letizia SantoniSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Nam Anh NgoSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Reyila SimayiCenter for Neuroscience, University of Camerino, Camerino, Italy.
Eleonora FiciaráCenter for Neuroscience, University of Camerino, Camerino, Italy.
Luisa de VivoCenter for Neuroscience, University of Camerino, Camerino, Italy.
Michele BellesiSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong link between sleep disturbances and AD progression, with disrupted sleep exacerbating AD progression through increased beta-amyloid and tau accumulation. This relationship indicates that improving sleep quality could slow disease progression and mitigate its effects on the brain. We investigated whether vestibular stimulation (rocking) could mitigate AD pathology in 3xTg mice (

Indexed as

Behavioral neuroscienceBiological sciencesNatural sciencesNeuroscience

Identifiers

PMID40115028
PMCPMC11925102

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.