Evidence map›Paper›PMID 40115077›Full record

ArticleFrontiers in cellular and infection microbiology2025

Identification and phylogenetic characterization of novel hunnivirus recombinant strains in cattle from Guangxi, China.

Guangxin Zhang, Yuhang Luo, Jiajie Li, Chang Cui, Kang Ouyang, Ying Chen, Zuzhang Wei, Yifeng Qin, Qingting Dong, Yan Pan and 1 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guangxin Zhang *Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Yuhang Luo *Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Jiajie LiLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Chang CuiLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Kang OuyangLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Ying ChenLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Zuzhang WeiLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Yifeng QinLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.
Qingting DongGuangxi Vocational University of Agriculture, Nanning, China.
Yan PanGuangxi Vocational University of Agriculture, Nanning, China.
Weijian HuangLaboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hunnivirus (HuV), a member of the Picornaviridae family, is a single-stranded RNA virus associated with gastrointestinal issues in animals and poses potential zoonotic risks. While HuV has been detected in various animals, its prevalence and genetic characteristics in cattle remain poorly understood. Methods: From 2021 to 2023, we collected 1,017 fecal samples from cattle across Guangxi, China, and analyzed them for HuV using RT-PCR. Phylogenetic and sequence analyses were conducted to assess the virus's genetic diversity and potential recombination events. Additionally, five HuV-positive samples were selected for whole-genome amplification and sequencing. Results: The overall prevalence of HuV was 3.05%, with significantly higher detection rates in diarrheic cattle (9.59%) compared to healthy cattle (2.54%). Regional prevalence varied, with the highest in Liuzhou (5.66%) and the lowest in Nanning (1.51%). Phylogenetic analysis identified a novel recombinant strain with distinct evolutionary patterns in the P3 genomic region. Sequence analysis revealed low homology in the VP1 and P1 regions compared to known genotypes, suggesting the classification of these strains as a new genotype. Additionally, the 5' untranslated region (5'UTR) analysis confirmed the presence of type II Internal Ribosome Entry Sites (IRES), showing up to 91.8% nucleotide similarity with human parechovirus HPeV-3. Discussion: These findings reveal significant genetic diversity and regional adaptation of HuV in cattle populations. The virus is associated with gastrointestinal symptoms, especially in areas with suboptimal farming conditions, and exhibits a potential for zoonotic transmission. This study provides a foundation for further research into the virus's pathogenicity and zoonotic risk, highlighting the need for continued surveillance to monitor its spread and evolution.

Indexed as

Cattle DiseasesPhylogenyRecombination, GeneticAnimalsCattleChinaFecesGenetic VariationGenome, ViralGenotypePicornaviridaePicornaviridae InfectionsPrevalenceRNA, ViralRNA, Viralcattlediarrheahunnivirusphylogenetic characterizationrecombinant

Identifiers

PMID40115077
PMCPMC11922853

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.