Evidence map›Paper›PMID 40115189›Full record

ArticleFrontiers in microbiology2025

COPB1-knockdown induced type I interferon signaling activation inhibits

Nana Li, Huiying Yang, Shan Zhang, Yufei Jiang, Yinhui Lin, Xiaoxiao Chen, Yuchen Zhang, Yonghui Yu, Xuan Ouyang, Yujun Cui and 2 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Kaempferol inhibitsFrontiers in microbiology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nana LiDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Huiying YangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Shan ZhangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Yufei JiangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Yinhui LinState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Xiaoxiao ChenState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Yuchen ZhangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Yonghui YuState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Xuan OuyangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.
Yujun CuiDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Yajun SongDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Jun JiaoState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medicine Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Methods: In this study, using fluorescently labeled Results: Among these, knockdown (KD) of two genes encoding subunits of the coatomer complex I (COPI) inhibited the pathogen's intracellular survival. Specifically, the knockdown of COPB1, a COPI subunit, significantly reduced the intracellular proliferation of Conclusion: Together, our findings advance the understanding of the mechanisms underlying

Indexed as

Chlamydia psittaciCOPB1GolgiSTINGtype I interferon

Identifiers

PMID40115189
PMCPMC11922848

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.