ArticleFrontiers in endocrinology2025
Association between neutrophil-percentage-to-albumin ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study from NHANES 2009-2018.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Neutrophil-Linked Inflammatory Mechanisms and Biomarkers in Diabetic Microvascular Complications.Diabetes & metabolism journal · 2026Review
- Association between novel indicators for inflammation and metabolism and kidney stones: a cross-sectional analysis of NHANES 2007-2018.BMC urology · 2026Article
- A novel inflammatory-nutritional index: NPAR-correlates with the severity of type 2 diabetic foot ulcers.Frontiers in nutrition · 2026Article
- Association between neutrophil percentage-to-albumin ratio and bone mineral density and prevalent osteoporosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- A machine learning model for diabetic retinopathy risk stratification using routine blood and urine parameters: insights into kidney-eye crosstalk.Frontiers in endocrinology · 2026Article
- Association Between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality and Cardiovascular Events in Patients with Diabetic Foot Ulcers: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- The association between sarcopenia and diabetic retinopathy: a mediation analysis of inflammatory biomarkers.Frontiers in endocrinology · 2026Article
- Neutrophil-to-albumin ratio: a novel predictor of osteoporosis in rheumatoid arthritis.Frontiers in immunology · 2025Article
- Integrating convolutional neural networks with ensemble methods for enhanced diabetes diagnosis: a multi-dataset evaluation.Frontiers in medicine · 2025Article
- Association of Neutrophil Percentage-To-Albumin Ratio With All-Cause and Cardiovascular Mortality in Chronic Kidney Disease.Inquiry : a journal of medical care organization, provision and financingArticle
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8 authors.
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Abstract
Background: The neutrophil-percentage-to-albumin ratio (NPAR), as a low-cost and easily accessible inflammatory biomarker, has garnered considerable attention in various disease studies in recent years. Specifically, existing research has suggested a significant correlation between NPAR and diabetic retinopathy, indicating its potential relevance to diabetic complications. However, despite diabetic kidney disease (DKD) being a complication that severely affects the quality of life of diabetic patients, the association between the prevalence of DKD and NPAR remains to be elucidated. Therefore, this study aims to explore the potential link between NPAR and DKD in patients with type 2 diabetes mellitus. Methods: We extracted complete data on neutrophil percentage, plasma albumin, serum creatinine, and urine albumin-to-creatinine ratio from the National Health and Nutrition Examination Survey database spanning from 2009 to 2018. Multivariable logistic regression models were employed to examine the relationship between NPAR levels and DKD, and conducted sensitivity tests, subsequently employing Generalized Additive Models combined with smooth curve fitting methods to explore the relationships among variables. Then, subgroup analyses were conducted on the association between NPAR and DKD to investigate changes in the relationship across different subgroups. Finally, Receiver operating characteristic curves were used to assess the predictive performance of the independent variable, NPAR, for the dependent variable, DKD. Results: A total of 2,263 participants were enrolled in this cross-sectional study. After adjusting for confounding factors, the odds ratio for DKD was 1.44 (95% CI: 1.08-1.90) for the second quartile group, 1.75 (95% CI: 1.33-2.31) for the third quartile group, and 2.95 (95% CI: 2.22-3.93) for the fourth quartile group. Among patients with type 2 diabetes mellitus, a positive correlation was observed between NPAR and DKD. Results from subgroup analyses showed no significant differences among different populations. Receiver operating characteristic (ROC) analysis indicated that NPAR had good predictive performance for DKD. Conclusion: The prevalence of DKD indicated a positive association with NPAR among individuals with T2DM. Additional large-scale prospective investigations may be helpful in corroborating these findings.
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