ArticleInternational journal of chronic obstructive pulmonary disease2025
The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis.
Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk.Comprehensive physiology · 2026Review
- Rebamipide attenuates LPS-induced acute lung injury in rats via modulation of macrophage polarization, PDE4B/cAMP/PKA/p-CREB and NF-κB signaling.Journal of molecular histology · 2026Article
- Dual-Phase Immunomodulation by the Bovine β-Casein Peptide KEMPFPK: Insights into Potential TLR Interaction and Gut Microbiota-Mediated Effects.Foods (Basel, Switzerland) · 2026Article
- Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs.bioRxiv : the preprint server for biology · 2026Article
- Host mScientific reports · 2026Article
- Gut microbiota dysbiosis and the gut-lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Background: Recently, numerous studies have explored the potential impact of gut microbiota on Chronic Obstructive Pulmonary Disease (COPD). However, the causal relationship between skin microbiota and COPD, as well as the differences and similarities between the relationships of gut microbiota and COPD, has not been thoroughly studied. Methods: We conducted a comprehensive two-sample Mendelian randomization (MR) analysis to investigate the relationships between gut and skin microbiota and COPD. The inverse variance weighted (IVW) method was used as the primary approach. MR-Egger, weighted median, and MR-PRESSO methods were used as supplementary approaches. Various sensitivity and stability analyses were conducted to validate the results. Genetic variations of gut microbiota were obtained from the FR02 cohort study. Genetic variations of skin microbiota were derived from the KORA FF4 and PopGen cohorts, with a total of 1,656 skin samples. GWAS data for COPD were obtained from the FinnGen consortium, including 18,266 COPD cases and 311,286 controls from European cohorts. Results: The results of IVW method of MR analysis showed that 10 gut microbiotas and 4 skin microbiotas were negatively associated with COPD [ Conclusion: This study revealed the causal relationships between gut and skin microbiota and COPD, offering fresh perspectives for the prevention, diagnosis, and management of COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.