Evidence map›Paper›PMID 40116060›Full record

ReviewSingapore medical journal2025

Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology.

Mayank Dalakoti, Ching Kit Chen, Ching-Hui Sia, Kian-Keong Poh

Abstract readReview
In one paragraph

Review in Singapore medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mayank DalakotiCardiovascular Metabolic Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ching Kit ChenCardiovascular Metabolic Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ching-Hui SiaCardiovascular Metabolic Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kian-Keong PohDepartment of Cardiology, National University Heart Centre, National University Health System, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractSubclinical atherosclerosis underlies most cardiovascular diseases, manifesting before clinical symptoms and representing a key focus for early prevention strategies. Recent advancements highlight the importance of early detection and management of subclinical atherosclerosis. This review underscores that traditional risk factor levels considered safe, such as low-density lipoprotein cholesterol (LDL-C) and glycated haemoglobin (HbA1c), may still permit the development of atherosclerosis, suggesting a need for stricter thresholds. Early-life interventions are crucial, leveraging the brain's neuroplasticity to establish lifelong healthy habits. Preventive strategies should include more aggressive management of LDL-C and HbA1c from youth and persist into old age, supported by public health policies that promote healthy environments. Emphasising early education on cardiovascular health can fundamentally shift the trajectory of cardiovascular disease prevention and optimise long-term health outcomes.

Indexed as

AtherosclerosisCardiologyCardiovascular DiseasesCholesterol, LDLGlycated HemoglobinHeart Disease Risk FactorsHumansRisk FactorsCholesterol, LDLGlycated Hemoglobin

Identifiers

PMID40116060
PMCPMC11991069

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.