Evidence map›Paper›PMID 40116436›Full record

ArticleCell transplantation

The Impact of Obesity on Autophagy in Human Adipose-Derived Mesenchymal Stromal Cells.

Li Xing, Ronscardy Mondesir, Logan M Glasstetter, Xiang-Yang Zhu, Bo Lu, Mina Al Saeedi, Gurparneet Kaur Sohi, Alfonso Eirin, Lilach O Lerman

Abstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li XingDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Ronscardy MondesirDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Logan M GlasstetterDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Xiang-Yang ZhuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Bo LuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Mina Al SaeediDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Gurparneet Kaur SohiDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Alfonso EirinDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3271-3887

Funding

Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4M
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
Noninvasive Evaluation of Renal Allograft Fibrosis by MRIR21AG062104 · NIA · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2021
$414k
NHLBI NIH HHS R01 HL158691NIA NIH HHS R21 AG062104NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R01 DK122734
6 · The paper itself

Abstract

Mesenchymal stromal cells (MSCs) possess therapeutic properties, which can be blunted by obesity. Autophagy, a cellular recycling process, is essential for MSC function. We investigated the mechanisms by which obesity affects the properties of MSCs, with a focus on autophagy. Adipose tissue was obtained from kidney donors [body mass index (BMI) <30 kg/m

Indexed as

Adipose TissueAutophagyMesenchymal Stem CellsObesityAdultFemaleHumansMaleMiddle Aged5-hydroxymethylcytosineautophagyLC3mesenchymal stromal cellsobesity

Identifiers

PMID40116436
PMCPMC11930488

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.