ArticleEuropean journal of nuclear medicine and molecular imaging2025
New compartment model for hepatic blood flow quantification in humans from 15O-water PET images.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Kinetic modeling with total body PET-current status and future applications.The British journal of radiology · 2026Review
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
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Authors and funding
3 authors.
Funding
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Abstract
backgroundDifferent compartment models are commonly used to derive crucial information about blood flow, metabolism, and oxygenation from the results of a dynamic positron emission tomography (PET) scan. However, compared to blood flow in many other organs of interest, the hepatic blood flow (HBF) quantification is challenging due to the dual blood supply of liver from both the hepatic artery and the portal vein (PV). Here, we introduce a new model that can be used to estimate the HBF in combination with an automatic volume of interest selection method. MATERIALS AND
methodsBy using the
resultsWe obtained the mean arterial HBF of 0.299±0.168 mL/min/mL, the mean portal HBF of 0.930±0.520 mL/min/mL, and the total HBF of 1.229±0.612 mL/min/mL with our new model. Based on earlier research, both these estimates and also the results of two earlier versions of the original dual-input model are realistic. Out of these three models, our proposed model performed the best in terms of MRE (p-values
conclusionThe HBF can effectively be estimated from
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