Evidence map›Paper›PMID 40116934›Full record

ArticleEuropean journal of clinical pharmacology2025

Genome-wide association study of direct oral anticoagulants and their relation to bleeding.

Sofia Attelind, Niclas Eriksson, Mia Wadelius, Pär Hallberg

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In one paragraph

Article in European journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sofia AttelindDepartment of Medical Sciences, Clinical Pharmacogenomics, Uppsala University, Uppsala, Sweden. sofia.attelind@medsci.uu.se.ORCID http://orcid.org/0000-0002-7631-7376
Niclas ErikssonDepartment of Medical Sciences, Clinical Pharmacogenomics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2152-4343
Mia WadeliusDepartment of Medical Sciences, Clinical Pharmacogenomics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6368-2622
Pär HallbergDepartment of Medical Sciences, Clinical Pharmacogenomics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3465-3280

Funding

Swedish Brain Foundation FO2020-0234Swedish Heart-Lung Foundation 20200777Vetenskapsrådet 2018-03307
6 · The paper itself

Abstract

purposeDirect oral anticoagulants (DOACs) are used to prevent and treat thromboembolic events in adults. We aimed to investigate whether pharmacogenomic variation contributes to the risk of bleeding during DOAC treatment.

methodsCases were recruited from reports of bleeding sent to the Swedish Medical Products Agency (n = 129, 60% men, 93% Swedish, 89% on factor Xa inhibitors) and compared with population controls (n = 4891) and a subset matched for exposure to DOACs (n = 353). We performed a genome-wide association study, with analyses of candidate single nucleotide polymorphisms (SNPs) and candidate gene set analyses.

resultsForty-four cases had major, 37 minor, and 48 clinically relevant non-major (CRNM) bleeding. When cases were compared with matched controls, BAIAP2L2 rs142001534 was significantly associated with any bleeding and major/CRNM bleeding (P = 4.66 × 10

conclusionBAIAP2L2, CYP3A5, ABCG2, and VWF may be associated with bleeding in DOAC-treated patients. The risk estimates of the candidate variants in CYP3A5 and ABCG2 were in the same direction as in previous studies. The Von Willebrand Factor gene (VWF) is linked to hereditary bleeding disorders, while there is no previous evidence of bleeding associated with BAIAP2L2.

Indexed as

AnticoagulantsFactor Xa InhibitorsHemorrhageAdministration, OralAgedAged, 80 and overATP Binding Cassette Transporter, Subfamily G, Member 2Case-Control StudiesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNeoplasm ProteinsPolymorphism, Single NucleotideSwedenABCG2 protein, humanAnticoagulantsATP Binding Cassette Transporter, Subfamily G, Member 2Factor Xa InhibitorsNeoplasm ProteinsABCG2Anticoagulant-induced bleedingBAIAP2L2CYP3A5Direct oral anticoagulants (DOACs)Drug-related side effects and adverse reactionsGenome-wide association study (GWAS)VWF

Identifiers

PMID40116934
PMCPMC12003525

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.