Evidence map›Paper›PMID 40117046›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Pea Peptide Modulates Abnormal Aβ Production in PC12 Cells Induced by Lead Exposure.

Ning Li, Ningning Cui, Ibrahim A Bakry, Yan Ma, Yongxia Cheng, Guangshan Zhao, Huijie Yang, Lianjun Song, Mingwu Qiao, Dan Hai and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ning LiCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China. ln8028@163.com.
Ningning CuiCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Ibrahim A BakryCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Yan MaCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Yongxia ChengCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Guangshan ZhaoCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Huijie YangCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Lianjun SongCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Mingwu QiaoCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Dan HaiCollege of Food Science and Technology, Henan Agricultural University, 63#Agricultural Road, Zhengzhou, 450000, China.
Gianni GalavernaFood and Drug Department, University of Parma, Parco Area delle Scienze, 17/a, PARMA, 43124, Italy.
Xianqing HuangKey Laboratory for Animal Immunology, Henan Academy of Agricultural Sciences, Huayuan Road 116, Zhengzhou, 450002, China. 15837184289@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead (Pb) exposure poses significant health risks, particularly in neurodegenerative diseases such as Alzheimer's disease (AD). This study investigates the neuroprotective effects of pea peptide (PP4) on PC12 cells exposed to Pb. Using Cell Counting Kit-8 (CCK-8), pretreatment with PP4 at 50 and 200 µM concentrations significantly improved cell viability compared to Pb-only treated cells (P < 0.05), indicating a protective effect. Moreover, Pb exposure led to increased Amyloid Precursor Protein (APP) expression at 10 and 20 µM after 24 h (P < 0.05), while β-site amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) levels were elevated across all concentrations tested (P < 0.05). We established that PP4 can mitigate Pb-induced cytotoxicity and reduce the expression of APP and BACE1 by activating the Phosphoinositide 3-kinase / Protein Kinase (PI3K/AKT) signaling pathway. This study highlights the potential of PP4 as a therapeutic agent in preventing neurotoxic damage associated with lead exposure, suggesting a novel approach for the management of AD.

Indexed as

Amyloid beta-PeptidesLeadNeuroprotective AgentsPeptidesPisum sativumAlzheimer DiseaseAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesCell SurvivalPC12 CellsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, ratLeadNeuroprotective AgentsPeptidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAPPAβ1−42BACE1LeadPea peptidePI3K/AKT

Identifiers

PMID40117046

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.