Evidence map›Paper›PMID 40117365›Full record

ArticleScience advances2025

Soft, stretchable conductive hydrogels for high-performance electronic implants.

Md Saifur Rahman, Ahnsei Shon, Rose Joseph, Anton Pavlov, Alex Stefanov, Myeong Namkoong, Heng Guo, Dangnghi Bui, Reid Master, Archita Sharma and 8 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  3. Article
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Md Saifur RahmanDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-0726-2399
Ahnsei ShonDepartment of Multidisciplinary Engineering, Texas A&M University, College Station, TX 77843, USA.
Rose JosephDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University, Bryan, TX 77807, USA.
Anton PavlovDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0004-8514-3285
Alex StefanovDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University, Bryan, TX 77807, USA.ORCID 0000-0003-3103-1259
Myeong NamkoongDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9209-7721
Heng GuoDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-7493-3773
Dangnghi BuiDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0005-4878-9965
Reid MasterDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0006-0066-1249
Archita SharmaDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-1447-4181
Jennifer LeeDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0003-0157-8357
Melissa RivasDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0008-1200-2392
Ananya ElatiDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0005-2267-676X
Yava Jones-HallDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-4030-9830
Feng ZhaoDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.
Hangue ParkDepartment of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea.ORCID 0000-0001-8641-2695
Michelle A HookDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University, Bryan, TX 77807, USA.
Limei TianDepartment of Biomedical Engineering, Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-1931-8567

Funding

Continuous metabolite and protein profiling for immune monitoringR35GM147568 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Limei Tian · 2022 to 2026
$1.8M
Refreshable Biosensors for Continuous Renal Function MonitoringR21EB029064 · NIBIB · TEXAS ENGINEERING EXPERIMENT STATION · PI TIAN, LIMEI · 2020 to 2020
$589k
NIBIB NIH HHS R21 EB029064NIGMS NIH HHS R35 GM147568
6 · The paper itself

Abstract

Conductive hydrogels are emerging as promising materials for electronic implants owing to their favorable mechanical and electrical properties. Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels are particularly attractive, but their preparation often requires toxic additives. Here, we introduced a nutritive sweetener, d-sorbitol, as a nontoxic additive to create soft and stretchable PEDOT:PSS conductive hydrogels. These hydrogels exhibit mechanical properties comparable with biological tissues, reducing adverse immune responses. The hydrogels can be patterned on elastic substrates using a simple, low-cost micromolding technique to fabricate soft and stretchable implantable devices for electrical stimulation and recording. The hydrogel electrodes show much lower electrochemical impedance and higher charge storage and injection capacity compared to platinum electrodes. In addition, the properties of hydrogels and devices remain stable after long-term storage and exposure to extreme conditions. We demonstrate the use of soft hydrogel-based electronic devices for effective electrical stimulation and high-quality electrical recordings in live animal models.

Indexed as

Electric ConductivityHydrogelsProstheses and ImplantsAnimalsElectric StimulationMicePolymersPolystyrenesHydrogelsPolymersPolystyrenes

Identifiers

PMID40117365
PMCPMC11927610

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.