Evidence map›Paper›PMID 40117366›Full record

ArticleScience advances2025

Emergence of a senescent and inflammatory pulmonary CD4

Sajad Moshkelgosha, Liran Levy, Shahideh Safavi, Sumiha Karunagaran, Gavin Wilson, Benjamin Renaud-Picard, Goodness Madu, Rashi Ramchandani, Jillian Oliver, Tatsuaki Watanabe and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sajad MoshkelgoshaToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-7892-388X
Liran LevyToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-6368-8015
Shahideh SafaviToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-6306-6662
Sumiha KarunagaranToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0009-0005-6345-9948
Gavin WilsonToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-3557-6320
Benjamin Renaud-PicardToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-3492-9486
Goodness MaduToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Rashi RamchandaniToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-6144-6423
Jillian OliverToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Tatsuaki WatanabeToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Ke Fan BeiToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-5008-4941
Betty JoeToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0009-0009-3634-9208
Qixuan LiBiostatistics Department, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-6618-3469
Ella HusztiBiostatistics Department, University Health Network, Toronto, ON, Canada.
May CheungToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
David HedleyDivision of Medical Oncology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Jonathan YeungToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-5759-3028
Shaf KeshavjeeToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-4547-8094
Tereza MartinuToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-9234-6807
Stephen JuvetToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-7243-556X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survival after lung transplantation is limited by chronic lung allograft dysfunction (CLAD), an alloimmune fibrotic process leading to death or retransplantation after a median of 6 years. Immunosuppression fails to prevent CLAD, suggesting the existence of drug-resistant alloimmune pathways. We used time-of-flight mass cytometry to identify cells enriched in the bronchoalveolar lavage of patients with subsequent acute lung allograft dysfunction (ALAD), a risk factor for CLAD. We show that CD4

Indexed as

CD4-Positive T-LymphocytesCellular SenescenceGraft RejectionLungLung TransplantationAdultAllograftsAnimalsBronchoalveolar Lavage FluidCytokinesFemaleHumansInflammationMaleMiceMiddle AgedCytokines

Identifiers

PMID40117366
PMCPMC11927631

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.