ReviewCurrent opinion in neurobiology2025
Expanding ligand-receptor interaction networks for axon guidance: Structural insights into signal crosstalk and specificity.
Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The neuro-immune axis in cancer: mechanisms of innervation-driven tumor progression and therapeutic opportunities.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Guidance of nascent axons to their targets is mediated by attractive and repulsive cues that activate receptors on the axonal growth cone. The number of ligand-receptor interactions implicated in axon pathfinding is still expanding, and large-scale cell-surface and extracellular protein interactome studies have revealed extensive crosstalk between signaling axes once thought to act independently. This raises the question how the apparent promiscuity of molecular interactions is compatible with specific signaling outcomes and effects on growth cone steering. Structural studies have provided insights into the modularity of binding interactions and shown the capacity of receptors to engage multiple ligands. Here, we review recent findings about the complexity of ligand-receptor interaction networks for axon guidance, and how structures of ligand-receptor complexes reveal mechanisms that may specify signaling output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.