ArticleCell stem cell2025
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
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Article in Cell stem cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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What it found
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Who cites it
14 citing papers in PubMed.
- Skeletal stem and progenitor cell niche organization, regulation and repair.Reviews in endocrine & metabolic disorders · 2026Review
- Not just fillers: the emerging role of bone marrow adipocytes in bone and bone marrow homeostasis.Biology open · 2026Review
- Transcriptomic analysis of bone marrow adipose tissue reveals enrichment in lipid transport in response to a Western diet.Endocrinology · 2026Article
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells.Bone research · 2026Article
- A novel non-invasive approach monitoring skeletal stem cell function throughJournal of orthopaedic translation · 2026Article
- Human cranial stem cells: developmental, pathologic, and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Artificial intelligence in orthopedic regenerative medicine: from design to clinical translational pathways.Frontiers in cell and developmental biology · 2026Review
- Article
- Hepatocyte Growth Factor-Mediated Chondrocyte Proliferation Induced by Adipose-Derived MSCs from Osteoarthritis Patients and Its Synergistic Enhancement by Hyaluronic Acid.International journal of molecular sciences · 2025Article
- Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.Nature communications · 2025Article
- Swiprosin-1 Negatively Regulates Osteoclast Differentiation and Bone Resorption via Akt/MAPK/NF-κB Pathway and αvβ3 Integrin-Dependent Signaling.International journal of molecular sciences · 2025Article
- Mesenchymal Stromal Cell-Derived Extracellular Vesicles as a Therapeutic Treatment for Osteosarcopenia: Crosstalk Among Neurons, Muscle, and Bone.International journal of molecular sciences · 2025Article
- Causality of Aging Hallmarks.Aging and disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Thomas H AmbrosiDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: thambrosi@ucdavis.edu.
Sahar TaheriDepartment of Computer Science and Engineering, Jacob's School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Kun ChenDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yuting WangDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ethan J HuntDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.
L Henry GoodnoughDepartment of Orthopaedic Surgery, Stanford Hospital and Clinics, Stanford, CA 94063, USA.
Matthew P MurphyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Holly M SteiningerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Malachia Y HooverInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Franco FelixInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kelly C WeldonDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.
Lauren S KoepkeInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jan SokolInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daniel Dan LiuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Liming ZhaoInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Stephanie D ConleyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wan-Jin LuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maurizio MorriChan Zuckerberg BioHub, San Francisco, CA 94158, USA.
Norma F NeffChan Zuckerberg BioHub, San Francisco, CA 94158, USA.
Noelle L Van RysselbergheDepartment of Orthopaedic Surgery, Stanford Hospital and Clinics, Stanford, CA 94063, USA.
Erika E WheelerDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA; Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
Yongheng WangDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
J Kent LeachDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA; Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
Augustine SaizDepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.
Aijun WangDepartment of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA; Department of Surgery, University of California Davis Health, Sacramento, CA 95817, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA 95817, USA.
George P YangDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Stuart GoodmanDepartment of Orthopaedic Surgery, Stanford Hospital and Clinics, Stanford, CA 94063, USA.
Julius A BishopDepartment of Orthopaedic Surgery, Stanford Hospital and Clinics, Stanford, CA 94063, USA.
Michael J GardnerDepartment of Orthopaedic Surgery, Stanford Hospital and Clinics, Stanford, CA 94063, USA.
Derrick C WanHagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Ludwig Center for Cancer Stem Cell Biology and Medicine at Stanford University, Stanford, CA 94305, USA.
Michael T LongakerInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: longaker@stanford.edu.
Debashis SahooDepartment of Computer Science and Engineering, Jacob's School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: dsahoo@ucsd.edu.
Charles K F ChanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Funding
Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0MInduced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2MInterrogation of individual cells to identify progenitors and their nichesU01HL099999 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2009 to 2015
$7.8MHSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9MMacrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9MHOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9MSummer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MIdentifying the superior ossification pathway for tissue engineered approaches to long bone repairR01AR079211 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT · 2021 to 2025
$1.9MIdentifying the human skeletal stem cell.R01DE027323 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2018 to 2022
$1.9MCellular and Mechanical Mechanisms Regulating Mandibular Distraction OsteogenesisR01DE026730 · NIDCR · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T · 2017 to 2021
$1.9MRejuvenating Skeletal Health Through A Novel Brain-Bone AxisU01AG086165 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLY A. INGRAHAM · 2024 to 2026
$1.5MNCATS NIH HHS UG3 TR002968NCATS NIH HHS UG3 TR003355NCI NIH HHS R00 CA151673NCI NIH HHS R01 CA086065NHLBI NIH HHS R01 HL058770NHLBI NIH HHS U01 HL099776NHLBI NIH HHS U01 HL099999NIAID NIH HHS R01 AI155696NIAMS NIH HHS R01 AR079211NIA NIH HHS K99 AG049958NIA NIH HHS K99 AG066963NIA NIH HHS R00 AG049958NIA NIH HHS R00 AG066963NIA NIH HHS U01 AG086165NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01 DE026730NIDCR NIH HHS R01 DE027323NIDCR NIH HHS R21 DE019274NIDCR NIH HHS R21 DE024230NIDCR NIH HHS R56 DE025597NIDCR NIH HHS U24 DE026914NIDDK NIH HHS R01 DK115600NIGMS NIH HHS R01 GM138385NIH HHS S10 OD028493
Abstract
The skeleton is one of the most structurally and compositionally diverse organ systems in the human body, depending on unique cellular dynamisms. Here, we integrate prospective isolation of human skeletal stem cells (hSSCs; CD45
Indexed as
Bone and BonesBone DevelopmentBone RegenerationRegenerationStem CellsAdultCell DifferentiationGene Regulatory NetworksHumansMaleOsteogenesisSingle-Cell Analysisbone agingBoolean relationshipsfibrous dysplasiafracture healinggene regulatory networkshuman skeletal stem cellnonunionskeletal development
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.