ArticleScientific reports2025
Micronutrients and polycystic ovary syndrome in the IEU OpenGWAS project: a two-Sample unidirectional Mendelian randomization analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A Biological Disease-Staging Model of Polyendocrine Metabolic Ovarian Syndrome: From Plasticity-Dominant States to Pathological Remodeling.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Clematis Chinensis Attenuates Hyperuricemia Through the Coordinated Regulation of Purine Metabolism and Inflammatory Responses: An Integrative Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction.Journal of Taibah University Medical Sciences · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder. Research suggests a potential link between certain micronutrients and PCOS development, but the exact cause-and-effect relationship is unclear. This research utilizes data from extensive genome-wide association studies (GWAS) to investigate the possible association between micronutrients and PCOS via Mendelian randomization (MR). The findings aim to inform future research and guide clinical practice. We performed a two-sample unidirectional MR analysis using genetic data from European populations. The MR analysis revealed no statistically significant association between the 11 micronutrient-related genes and PCOS (all P-values > 0.05). Phosphate, magnesium, folate, vitamin B12, D, iron, selenium, and copper odds ratios (ORs) less than 1, calcium, vitamin C, and zinc ORs greater than 1. Sensitivity analyses revealed no indications of heterogeneity, pleiotropy, or outliers, hence affirming the robustness of these findings. High serum phosphate, magnesium, folate, vitamin B12, D, iron, selenium and copper levels may be potentially protective against PCOS. High serum calcium, vitamin C and zinc levels may be potential risk factors for PCOS. These insights are important for understanding PCOS's pathophysiology and improving clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.