Evidence map›Paper›PMID 40119187›Full record

ArticleNeurotoxicity research2025

Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage.

Thaís Antonia Alves Fernandes, Aurore Tourville, Ismaila Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos, Maurício Dos Santos Pereira, Maxime Oblaza, Jean-Michel Brunel, Laurent Ferrié, Rita Raisman-Vozari and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thaís Antonia Alves FernandesSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.
Aurore TourvilleSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.
Ismaila CissSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.
Rafaela Ribeiro SilvaSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.
Bianca Andretto de MattosSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.ORCID http://orcid.org/0000-0002-6325-1064
Maurício Dos Santos PereiraSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.ORCID http://orcid.org/0000-0001-9012-7379
Maxime OblazaSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.
Jean-Michel BrunelAix Marseille Univ, Inserm, Membranes et Cibles Thérapeutiques, Service de Santé des Armées, Marseille, 13385, France.ORCID http://orcid.org/0000-0002-9355-8980
Laurent FerriéUniversité Paris-Saclay, BioCIS, CNRS, Orsay, 91190, France.ORCID http://orcid.org/0000-0002-1171-205X
Rita Raisman-VozariSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France.ORCID http://orcid.org/0000-0003-4873-3935
Bruno FigadèreUniversité Paris-Saclay, BioCIS, CNRS, Orsay, 91190, France.ORCID http://orcid.org/0000-0003-4226-8489
Elaine Del-BelDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, SP, 14049-904, Brazil. eadelbel@usp.br.ORCID http://orcid.org/0000-0002-4158-7376
Patrick Pierre MichelSorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, 75013, France. patrick.michel@icm-institute.org.ORCID http://orcid.org/0000-0001-5607-3119

Funding

CAPES 88887595435/2020-00Capes-Cofecub 88887.710933/2022-00; Me 928/19Institut Carnot CM157
6 · The paper itself

Abstract

This study aimed to investigate the neuroprotective potential of the tetracycline (TC) antibiotic oxytetracycline (OT) and its non-antibiotic derivative 4-dedimethylamino 12a-deoxy-oxytetracycline (DOT), in experimental conditions that mimic the gradual loss of dopamine (DA) neurons in Parkinson's disease (PD). Specifically, we established a model system of mouse midbrain cultures where DA neurons progressively die when exposed to an iron-containing medium. We found that OT (EC

Indexed as

Dopaminergic NeuronsIronMesencephalonNeuroprotective AgentsOxidative StressOxytetracyclineAnimalsCells, CulturedMiceMice, Inbred C57BLReactive Oxygen SpeciesIronNeuroprotective AgentsOxytetracyclineReactive Oxygen SpeciesDopamineIronNeurodegenerationNon-antibiotic tetracyclinesOxidative stressParkinson’s disease

Identifiers

PMID40119187

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.