ArticleBMC neurology2025
Altered brain-derived neurotrophic factor levels and oxidative stress in REM sleep deprivation: a rat model study.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Associations between plasma BDNF, VEGF, and EGF and cognition in drug-naïve schizophrenia with and without sleep disturbances.European archives of psychiatry and clinical neuroscience · 2026Article
- Maternal sleep deprivation and developmental programming of brain aging trajectories in offspring.Biogerontology · 2026Review
- Development of an automated REM sleep deprivation device for mice in neuroscience research.HardwareX · 2026Article
- The correlation between serum markers of oxidative stress and fatigue and related factors in minimally disabled patients with relapsing-remitting multiple sclerosis.Scientific reports · 2026Article
- Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment.Neurochemical research · 2026Article
- Sleep architecture and serum biomarker heterogeneity in obstructive sleep apnea: a cross-sectional study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Sleep Deprivation and Alzheimer's Disease: A Review of the Bidirectional Interactions and Therapeutic Potential of Omega-3.Brain sciences · 2025Review
- The role of melatonin in affecting cognitive dysfunction in acute sleep deprivation mice through the nuclear factor kappaB pathway and oxidative stress.Translational neuroscience · 2025Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain-derived neurotrophic factor (BDNF) is among the modulators associated with cognition and sleep that play a role in sleep disorders. This study aimed at investigating the effects of chronic sleep deprivation and REM sleep deprivation on BDNF levels and oxidative stress markers.
methodsA total of 24 healthy male Wistar albino rats were separated into 3 groups as REM sleep deprivation group, control sleep deprivation group and control group. To create models of 21-day REM sleep deprivation and control sleep deprivation, we used the platform technique. After 21 days blood BDNF, brain tissue BDNF, brain tissue malondialdehyde, glutathione, ascorbic acid, nitrite and nitrate were evaluated.
resultsCompared with the control group, control sleep deprivation group showed a significant increase in brain tissue levels of BDNF (p = 0.038), whereas a significant decrease was observed in the levels of glutathione (GSH) and nitric oxide (NO) (p:0.036). No statistical difference was observed between the blood levels of BDNF in either group (p: 0.795).
conclusionOur results showed decreases in GSH and NO levels and increases in malondialdehyde levels in the sleep deprivation models, reflecting oxidative stress in the brain. Additionally, we observed increases in brain BDNF levels in the control sleep deprivation model.
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