ArticleDiabetology & metabolic syndrome2025
Association between the Triglyceride-glucose index and fragility fractures among US adults: insights from NHANES.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of frailty with fragility fractures and all‑cause mortality in adults: evidence from the National Health and Nutrition Examination Survey.BMC musculoskeletal disorders · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride-glucose (TyG) index, a recognized marker for insulin resistance, holds potential implications for skeletal health. However, its relationship with fragility fractures remains uncertain. We aimed to elucidate the association between the TyG index and fragility fractures in the general US population.
methodsCross-sectional data of 25,082 participants were obtained from the National Health and Nutrition Examination Survey. The association between the TyG index and fragility fractures was investigated using univariate and weighted multivariate logistic regression as well as restricted cubic spline (RCS) regression models. The least absolute shrinkage and selection operator regression with ten-fold cross-validation was employed to identify key variables, leading to the development of a nomogram model. Calibration and receiver operating characteristic curves were utilized to evaluate the model's validity.
resultsThe overall prevalence of fragility fractures among participants was 1.10%. After adjusting for confounders, the TyG index exhibited a robust association with the risk of fragility fractures (odds ratio, 1.94; 95% confidence interval, 1.31-2.88; P < 0.001). RCS regression demonstrated a positive linear relationship between the TyG index and fragility fractures. The predictive nomogram, incorporating the TyG index and other clinical factors, demonstrated favorable predictive performance (consistency index = 0.901).
conclusionsElevated TyG index levels were significantly correlated with the risk of fragility fractures in the general US population. These findings suggest that the TyG index may serve as a predictive marker for fragility fractures, underscoring the importance of early intervention and improved fracture risk assessment tools in clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.