Evidence map›Paper›PMID 40119470›Full record

ArticleDiabetology & metabolic syndrome2025

Leukocyte telomere length change in children with obesity in the context of an isocaloric fructose restriction intervention.

Janet M Wojcicki, Elissa Epel, Jue Lin, Viva Tai, Jean-Marc Schwarz, Susan M Noworolski, Ayca Erkin-Cakmak, Kathleen Mulligan, Alejandro Gugliucci, Rob H Lustig

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In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janet M WojcickiDivision of Pediatric Gastroenterology, Hepatology and Nutrition, University of California, San Francisco, 550 16th Street, 4th Floor, San Francisco, CA, 94134-0136, USA. Janet.wojcicki@ucsf.edu.
Elissa EpelDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, USA.
Viva TaiDepartment of Medicine, University of California, San Francisco, USA.
Jean-Marc SchwarzBasic Sciences, College of Osteopathic Medicine, Touro University-California, Vallejo, CA, USA.
Susan M NoworolskiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Ayca Erkin-CakmakDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Kathleen MulliganDepartment of Medicine, University of California, San Francisco, USA.
Alejandro GugliucciDepartment of Research, College of Osteopathic Medicine, Touro University-California, Vallejo, CA, USA.
Rob H LustigDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have evaluated changes in leukocyte telomere length (LTL) over a short time period (e.g. 1 week). LTL shortening is accelerated by exposure to inflammation and reactive oxygen species (ROS) damage.

methodsIn the context of an isocaloric fructose restriction study that was conducted with 43 Black and Latinx children over a 9-day period, we evaluated the relationship between metabolic health at baseline and metabolic changes and LTL at baseline and %LTL change over the follow-up period. Linear regression models were used to assess associations between metabolic correlates and LTL at baseline and LTL changes over 9 days.

resultsOverall children lost - 0.05 ± 0.14 T/S units or - 2.98 ± 8.74% total change over the follow-up period. Higher concentrations of HDL-C, APO-AI and a greater % of large HDL-C at baseline were associated with reduced LTL attrition rates at day 10 (p < 0.01; p < 0.01 and p = 0.02 respectively). Increases in APO-AI over the follow-up period were associated with increased LTL attrition over the follow-up period (p = 0.03).

conclusionsIn this short term isocaloric fructose restriction study, LTL at baseline and changes in LTL over 9 days were associated with HDL-C and APO-AI and not with any other non-HDL-C lipids. Additional, larger studies are necessary to better understand the interplay between short term fructose restriction, LTL changes and HDL-C/APO-AI.

Identifiers

PMID40119470
PMCPMC11929270

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.