Evidence map›Paper›PMID 40120037›Full record

ArticleTranslational stroke research2025

Higher Time to Peak after Stent Implantation in Symptomatic High-Grade Intracranial Atherosclerotic Stenosis is Related to In-Stent Restenosis.

Longhui Zhang, Haoyu Zhu, Yupeng Zhang, Fangguang Chen, Dapeng Sun, Yufan Liu, Chuhan Jiang, Zhongrong Miao, Baixue Jia

Abstract read
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In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Longhui Zhang *Interventional Neuroradiology Department, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Haoyu Zhu *Department of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yupeng ZhangDepartment of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fangguang ChenInterventional Neuroradiology Department, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dapeng SunInterventional Neuroradiology Department, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yufan LiuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chuhan JiangDepartment of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhongrong Miao *Interventional Neuroradiology Department, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. zhongrongm@163.com.
Baixue Jia *Interventional Neuroradiology Department, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. beckyberry@163.com.

Funding

National Natural Science Foundation of China 82401538the Natural Science Foundation of Beijing Municipality 7212007
6 · The paper itself

Abstract

Little is known about the association between periprocedural hemodynamics and in-stent restenosis (ISR) following stent implantation in patients with symptomatic intracranial atherosclerotic stenosis (ICAS). This study aims to identify periprocedural hemodynamics that may be associated with ISR. Subjects were selected from the NOVA trial (The First-in-man Trial Evaluating the Safety and Efficacy of the NOVA Intracranial Stent Trial). ISR was defined as greater than 50% stenosis of the luminal diameter within or immediately adjacent to (within 5 mm) the implanted stent. Periprocedural hemodynamics, including cerebral blood flow, cerebral blood volume, mean transit time, and time to peak (TTP), were derived from the time-density curve generated from digital subtraction angiography using the fast Fourier transform algorithm. Of the 263 patients enrolled in the NOVA trial, 176 with symptomatic high-grade ICAS who underwent stent implantation were included in this study. Of these, 35 (19.9%) were diagnosed with ISR at the one-year follow-up. No significant differences in pre-procedure hemodynamics were observed between stent groups and between the ISR groups and the non-ISR group. Higher post-procedure TTP (OR, 1.95; 95% CI, 1.26-3.02), the use of bare-metal stents (OR, 5.40; 95% CI, 2.21-13.19), and higher post-procedure residual stenosis (OR, 1.08; 95% CI, 1.03-1.13) were independent factors associated with ISR. Higher post-procedure TTP, the use of bare-metal stents, and higher post-procedure residual stenosis were independent factors associated with ISR. The combined use of periprocedural hemodynamics and clinical factors may help predict ISR in patients with symptomatic high-grade ICAS.

Indexed as

Intracranial ArteriosclerosisStentsAgedAngiography, Digital SubtractionCerebrovascular CirculationConstriction, PathologicFemaleHemodynamicsHumansMaleMiddle AgedTime FactorsDrug-eluting stentsHemodynamicsIn-stent restenosisIntracranial atherosclerotic stenosis

Identifiers

PMID40120037

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.