ArticleProbiotics and antimicrobial proteins2026
Antibacterial, Antioxidant, and Anti-inflammatory Activities of Lacticaseibacillus paracasei Lysates Isolated from Fermented Palm Sap.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Postbiotics and paraprobiotics in food biochemistry mechanisms stability and nutritional applications.NPJ science of food · 2026Review
- Functional characteristics of peptides from whey proteins fermented with lactic acid bacteria isolated from Dongchimi.Food science of animal resources · 2026Article
- Lyophilized Cell-Free Supernatants ofLife (Basel, Switzerland) · 2025Article
- Diversity ofFoods (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Paraprobiotics are inactivated microbial cells or cell fractions that confer health benefits to the consumer, and possess the ability to regulate both the adaptive and innate immune systems. They exhibit anti-inflammatory, antiproliferative, antioxidant properties, and antimicrobial activities. The aim of this study is to evaluate these activities of Lacticaseibacillus paracasei lysates isolated from fermented palm sap. The bacterial cell lysates were prepared via sonication, and their antibacterial activity was assessed against three pathogens using agar well diffusion assay. Antioxidant activity was evaluated using DPPH and ABTS radical scavenging assays. Cytotoxicity and anti-inflammatory activity were determined in LPS-stimulated RAW 264.7 cells by measuring nitric oxide production, secretion, and mRNA level of cytokines (IL-1β, IL-6, and IL-10). Among the lysates, L. paracasei T1901 demonstrated the strongest antibacterial activity against Escherichia coli, Bacillus cereus, and Acinetobacter baumannii. Most lysates exhibited potent antioxidant activity, especially T0601 that showed the highest DPPH and ABTS radical scavenging activities. In LPS-stimulated RAW 264.7 cells, the lysates effectively reduced nitric oxide levels and suppressed the production of pro-inflammatory cytokines (IL-1β and IL-6); simultaneously, the lysates enhanced immunosuppressive cytokine IL-10 secretion. Furthermore, no cytotoxic effect was observed in the lysate-treated RAW 264.7 cells. The study highlights the potential of L. paracasei lysates as multifunctional agents with antibacterial, antioxidant, and anti-inflammatory properties. These findings support their application in developing functional foods or therapeutic agents for managing oxidative stress and inflammatory diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.