Evidence map›Paper›PMID 40120236›Full record

ArticleHuman immunology2025

Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation.

Harry Pickering, Janice Arakawa-Hoyt, Megan Llamas, Kenichi Ishiyama, Yumeng Sun, Rajesh Parmar, Subha Sen, Suphamai Bunnapradist, Steven R Hays, Jonathan P Singer and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Harry PickeringDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Janice Arakawa-HoytDepartment of Microbiology and Immunology, University of California, San Francisco, CA, United States.
Megan LlamasDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Kenichi IshiyamaDepartment of Microbiology and Immunology, University of California, San Francisco, CA, United States.
Yumeng SunDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Rajesh ParmarDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Subha SenDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Suphamai BunnapradistDivison of Nephrology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Steven R HaysDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Jonathan P SingerDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States.
Joanna M SchaenmanDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Lewis L LanierDepartment of Microbiology and Immunology, University of California, San Francisco, CA, United States.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Daniel R CalabreseDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States; Medical Service, San Francisco VA Health Care System, San Francisco, CA, United States.
John R GreenlandDepartment of Medicine, University of California San Francisco, San Francisco, CA, United States; Medical Service, San Francisco VA Health Care System, San Francisco, CA, United States. Electronic address: john.greenland@ucsf.edu.
CMV Systems Immunobiology Group

Funding

Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, SARWAL, MINNIE M · 2017 to 2021
$11.2M
Telomere Dysfunction as a cause of Chronic Lung Allograft DysfunctionR01HL151552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2024
$1.6M
BLRD VA IK2 BX005301CSRD VA I01 CX002011NHLBI NIH HHS R01 HL151552NIAID NIH HHS U19 AI128913
6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection threatens outcomes across solid organ transplantation, but organ-specific differences in CMV immunity are incompletely understood. We investigated whether lung and kidney CMV infection drove similar immune profiles, hypothesizing that CMV-associated T cells would be associated with graft function. We longitudinally examined 41 lung transplant (LTx) recipients and 31 kidney transplant (KTx) recipients with CMV viremia, alongside non-viremic controls. We performed flow cytometry and single-cell protein and transcriptomic profiling (CITE-seq) on blood cells. Chronic lung allograft dysfunction (CLAD)-free survival and glomerular filtration rate decline-free survival were assessed by Cox proportional-hazards models. Terminal effector memory (TEMRA) CD8

Indexed as

CD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsKidney TransplantationLung TransplantationMemory T CellsViremiaAdultAgedCD57 AntigensFemaleHumansLectins, C-TypeMaleMiddle AgedReceptors, ImmunologicCD57 AntigensKLRG1 protein, humanLectins, C-TypeReceptors, ImmunologicCD8(+) T cellsChronic allograft dysfunctionCytomegalovirusImmune profilingSolid organ transplantation

Identifiers

PMID40120236
PMCPMC12897500

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.