Evidence mapPaperPMID 40121331Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.

Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caroline G BordenDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Veronika ShabanovaDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Sarah N TaylorDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6948-8329
Catherine O BuckDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA. catherine.buck@yale.edu.ORCID http://orcid.org/0000-0003-3731-943X

Funding

Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
Short Term Research Training: Students in Health Professional SchoolsT35DK104689 · YALE UNIVERSITY · 2025 to 2025
$181k
Preventing Obesity in Preterm InfantsK23HD104907 · YALE UNIVERSITY · 2025 to 2025
$167k
Doris Duke Charitable Foundation (DDCF) 2021266NCATS NIH HHS UL1 TR001863NICHD NIH HHS K23 HD104907NIDDK NIH HHS T35 DK104689U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001863U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) T35DK104689
6 · The paper itself

Abstract

objectiveCharacterize changes in neonatal energy metabolism hormones in first postnatal week. STUDY

designConcentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.

resultAmong 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).

conclusionIn this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.

Indexed as

AdipokinesDiabetes, GestationalInfant, PrematurePregnancy in DiabeticsAdiponectinAdultFemaleFetal BloodGhrelinHumansInfant, NewbornInsulinLeptinLinear ModelsMalePregnancyAdipokinesAdiponectinGhrelinInsulinLeptinResistin

Identifiers

PMID40121331
PMCPMC12278066

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.