Evidence map›Paper›PMID 40121366›Full record

ArticleBone marrow transplantation2025

Kidney function after nonmyeloablative hematopoietic cell transplant for sickle cell disease.

Emily Limerick, Matthew M Hsieh, Mauricio Barretto, Neal Jeffries, Clarissa Diamantidis, Yuliya Lokhnygina, Ritika Menon, Santosh L Saraf, Courtney D Fitzhugh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Management of Kidney Disease with Sickle Cell Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily LimerickNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Matthew M HsiehNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mauricio BarrettoNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Neal JeffriesNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Clarissa DiamantidisDepartment of Medicine, Department of Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Yuliya LokhnyginaDivision of Biostatistics, Duke University School of Medicine, Durham, NC, USA.
Ritika MenonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Santosh L Saraf *Division of Hematology & Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, IL, USA. ssaraf@uic.edu.ORCID http://orcid.org/0000-0002-8584-4194
Courtney D Fitzhugh *National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Courtney.Fitzhugh@nih.gov.ORCID http://orcid.org/0000-0002-5306-7167

Funding

Nonmyeloablative haploidentical peripheral blood stem cell transplantation in congenital anemiasZIAHL006211 · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2025 to 2025
$3.1M
Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell diseaseU01HL156620 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$842k
Intramural NIH HHS ZIA HL006211NHLBI NIH HHS U01 HL156620U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1U01HL156620-01
6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is potentially curative for patients with sickle cell disease (SCD). Both SCD and HCT cause kidney damage. This study analyzed data from 160 patients who received nonmyelablative HCT for SCD. Renal function was assessed at baseline and annually for 3years. The rate of new-onset eGFR <60 ml/min/1.73m

Indexed as

Anemia, Sickle CellHematopoietic Stem Cell TransplantationKidneyTransplantation ConditioningAdolescentAdultChildFemaleFollow-Up StudiesGlomerular Filtration RateHumansMaleMiddle AgedYoung Adult

Identifiers

PMID40121366
PMCPMC12716101

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.