Evidence map›Paper›PMID 40123187›Full record

ArticleJournal of aging and health2025

Subjective Cognitive Impairment (SCI) and Future Dementia Risk in the National Health and Aging Trends Study (NHATS) During 2012-2019.

Emmanuel F Drabo, Jennifer L Wolff, Linda C Chyr, Julie Zissimopoulos, Bryan Lau

Abstract read
In one paragraph

Article in Journal of aging and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emmanuel F DraboDepartment of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-7470-4391
Jennifer L WolffDepartment of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Linda C ChyrClinical Analytics, Elevance Health, Inc, Wilmington, DE, USA.
Julie ZissimopoulosSol Price School of Public Policy, University of Southern California, Los Angeles, CA, USA.
Bryan LauDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research - Research Ed ComponentP30AG059298 · NIA · JOHNS HOPKINS UNIVERSITY · PI Joseph John Gallo, ROLAND J. THORPE · 2018 to 2026
$7.1M
Remote Data Enclave Core (RDEC)P30AG066587 · NIA · JOHNS HOPKINS UNIVERSITY · PI KATHERINE A ORNSTEIN · 2020 to 2026
$6.7M
NIA NIH HHS P30 AG059298NIA NIH HHS P30 AG066587
6 · The paper itself

Abstract

BackgroundSubjective cognitive impairment (SCI), assessed in national surveys, offers potential for dementia monitoring and early detection. However, its causal link to dementia risk remains unclear.ObjectiveTo evaluate whether SCI causally affects dementia risk in U.S. older adults (≥65 years), considering mortality as a competing risk.MethodsUsing data from 1622 dementia-free older adults in the National Health and Aging Trends Study (NHATS) during 2011-2019, we estimated total, direct, and separable effects of SCI on dementia and mortality risks.ResultsSCI was reported by 7.6% at baseline and associated with a twofold increased dementia risk over 8 years (RR: 1.95, 95% CI: 1.07-3.07) and lower mortality risk (RR: 0.31, 95% CI: 0.10-0.67). Direct effect analysis indicated a potential direct causal link between SCI and dementia.ConclusionsSCI predicts dementia onset and inversely affects mortality, highlighting the importance of early detection and precise analytic approaches.

Indexed as

Cognitive DysfunctionDementiaAgedAged, 80 and overAgingFemaleHumansMaleRisk FactorsUnited StatesAlzheimer’s disease and related dementiascompeting risksNHATSprobable dementiasubjective cognitive impairment

Identifiers

PMID40123187
PMCPMC12978034

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.