ArticleObesity (Silver Spring, Md.)2025
Food insecurity promotes adiposity in mice.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- The Direct and Moderating Effect of Food Insecurity on Obesity-A Cross-Sectional Study.Food science & nutrition · 2026Article
- Intermittency and Predictability of a Cafeteria Diet Shape Food Intake, Adiposity, and Neurobehavioral Outcomes in Rats.Nutrients · 2026Article
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- Ability to predict irregular periods of food depriviation improves body-weight regulation and reduces weight gain in food-insecure starlings.Royal Society open science · 2025Article
- Food insecurity promotes adiposity in mice.Obesity (Silver Spring, Md.) · 2025Article
- Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice.Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe obesity epidemic, driven by a complex interplay of environmental and biological factors, remains a significant global health challenge. Herein, we investigate the impact of food insecurity, characterized by unpredictable food access, on the regulation of body weight and body composition in mice.
methodsMale and female C57BL/6J mice were subjected to a combination of intermittent fasting and calorie restriction to simulate food insecurity.
resultsOur new model demonstrates that food insecurity increases fat mass and decreases lean mass in both sexes on a standard chow diet. Additionally, high-fat diet-fed male mice exposed to the food insecurity paradigm show decreased lean mass despite being in positive energy balance. Transcriptomic analysis of white adipose tissue from food-insecure male mice revealed upregulation of metabolic pathways associated with fat mass expansion and downregulation of immune response-related transcripts.
conclusionsThese findings underscore the role of food insecurity in driving metabolic adaptations that favor fat storage. Understanding this paradoxical link between food insecurity and adiposity is crucial for developing targeted interventions to address the disproportionate incidence of obesity in socioeconomically disadvantaged populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.