ArticleJournal of Parkinson's disease2025
Is motor reserve associated with a rapid progression of Parkinson disease?
Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Physical activity promotes clinical benefits beyond dopaminergic preservation in Parkinson's disease: a longitudinal analysis of the PPMI cohort.Neurological research and practice · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundThe motor reserve estimates (MRes) derived from a residual approach correlate with motor severity in Parkinson's disease (PD), leaving the independent effect of motor reserve on clinical outcomes unclear.ObjectiveInvestigate the independent influence of motor reserve on the long-term outcome.MethodsUsing the Parkinson's Progression Markers Initiative (PPMI) and Pusan National University Hospital (PNUH) datasets, we investigated the association of MRes with progression of motor severity as well as risk of phenoconversion to Hoehn & Yahr (H&Y) stage 3. Two MRes types were calculated: (1) original MRes, negative conversion of standardized residuals from a generalized linear model (GLM) between putaminal dopamine transporter (DAT) levels and motor severity, and (2) modified MRes, standardized residuals from the GLM between original MRes and motor scores.ResultsOriginal MRes correlated with baseline motor scores, while modified MRes did not. Modified MRes in both cohorts were associated with a rapid increase in motor severity (linear mixed effect model, interaction between MRes and disease duration; PPMI, Movement Disorder Society sponsored Unified Parkinson Disease Rating Scale part III [MDS-UPDRS III], estimate 2.248 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.