Evidence map›Paper›PMID 40123481›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study.

Yakubu Bene-Alhasan, Sanyog G Shitole, Petra Bůžková, Calvin H Hirsch, Joachim H Ix, Jorge R Kizer, David S Siscovick, Nirupa R Matthan, Alice H Lichtenstein, Luc Djoussé and 1 more

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In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yakubu Bene-AlhasanDepartment of Medicine, MedStar Health/Georgetown University, Baltimore, MD 21218, USA.ORCID 0000-0001-9086-3894
Sanyog G ShitoleCardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.
Petra BůžkováDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Calvin H HirschDivision of General Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Joachim H IxDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
Jorge R KizerCardiology Section, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.
David S SiscovickDivision of Research, Evaluation and Policy, The New York Academy of Medicine, New York, NY 10029, USA.
Nirupa R MatthanJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-7037-9779
Alice H LichtensteinJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-1053-9478
Luc DjousséDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9902-3047
Kenneth J MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-8450-6970

Funding

Exceptional aging: 12 year trajectories to functionR01AG023629 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2005
$2.6M
NHLBI NIH HHSNIA NIH HHS R01AG053325NIH HHSNINDS NIH HHS K24AG065525NINDS NIH HHS R01AG023629
6 · The paper itself

Abstract

contextTotal fasting non-esterified fatty acid (NEFA) levels have been associated with mortality. The corresponding associations with NEFA levels following an oral glucose tolerance test (OGTT) and with individual fasting NEFA species are unclear.

objectiveWe evaluated the associations of post-load NEFA, fasting subclasses and individual NEFA with mortality.

methodsThe Cardiovascular Health Study is a population-based cohort study of community-dwelling adults over 64 years of age from 4 US communities that began in 1989-1990. Participants had total NEFA measured enzymatically before and 2 hours after an OGTT from archived serum samples collected in 1996-1997. Fasting individual NEFA were also measured using gas chromatography. Cox proportional hazard models were used to evaluate adjusted hazard ratios (aHR) for mortality associated with fasting and post-load total NEFA, and fasting individual and fatty acid subclasses (saturated, monounsaturated, n-3 and n-6 polyunsaturated, and trans).

resultsThe final population included 1996 participants (mean age 78 years; 60.5% female). Over a median 11-year follow-up period, 1678 participants died. Total fasting NEFA was associated with higher risk of all-cause mortality (aHR per SD: 1.17, 95% CI [1.10-1.23]). Total post-load NEFA was not associated with mortality. Among subclasses, only monounsaturated fatty acid (MUFA) was associated with total mortality (aHR 1.24, 95% CI [1.09-1.41]). For individual NEFAs, nervonic acid (aHR 1.06, 95% CI [1.01-1.12]), petroselaidic acid (aHR 1.21, 95% CI [1.03-1.42]), and eicosapentaenoic acid (aHR 0.90, 95% CI [0.82-0.99]) were associated with all-cause mortality.

conclusionIndividual fasting NEFAs represent attractive candidates for medical and public health interventions aimed at improving survivorship in older adults and should be investigated further.

Indexed as

Cardiovascular DiseasesFatty Acids, NonesterifiedAgedAged, 80 and overCause of DeathCohort StudiesFastingFemaleGlucose Tolerance TestHumansMaleMiddle AgedRisk FactorsUnited StatesFatty Acids, Nonesterifiedcancer mortalitycardiovascular mortalityfree fatty acidolder adultspreventive medicine

Identifiers

PMID40123481
PMCPMC12527442

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.