ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Adherence to unilateral hypoglossal nerve stimulation and changes in Epworth Sleepiness Scale scores.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Automatic activation of neurostimulation for central sleep apnea results in high nightly usage.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- The benefits of capturing patient-reported outcome measures for treatment of obstructive sleep apnea with hypoglossal nerve stimulation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
STUDY
objectivesEffective treatment of obstructive sleep apnea depends on efficacy and adherence. The objective of this analysis was to examine the association between adherence to unilateral hypoglossal nerve stimulation (Inspire upper airway stimulation) and changes in daytime sleepiness.
methodsParticipants were adults treated with unilateral hypoglossal nerve stimulation enrolled in the ADHERE Registry. All participants included in the analysis completed a final visit 1-2 years following implantation. Outcomes were the change in Epworth Sleepiness Scale (ESS) score and normalization of a baseline abnormal ESS score (baseline ESS > 10 and final ESS ≤ 10). Statistical analyses examined the association between objective therapy adherence and ESS outcomes, with multiple regression including adjustment for age, sex, race, ethnicity, body mass index, and apnea-hypopnea index-defined responder status.
resultsThe analysis included 1,147 participants who were primarily middle-aged (59.7 ± 10.5 years), overweight (body mass index: 29.1 ± 3.7), White (95.8%), male (76.8%), and with severe obstructive sleep apnea (apnea-hypopnea index: 35.12 ± 14.81). ESS scores decreased from 11.3 ± 5.5 at baseline to 6.9 ± 4.6 at the final visit. Of those with baseline ESS > 10, 68% (441/644) achieved normalized ESS scores at the final visit. Multiple regression analyses showed that each additional hour/night of therapy use was associated with a decrease in ESS score (0.17,
conclusionsAdherence to hypoglossal nerve stimulation is associated with improvement in daytime sleepiness symptoms and increased odds of achieving normalization of daytime sleepiness. CITATION: Commesso EA, Haghighian C, Kezirian EJ. Adherence to unilateral hypoglossal nerve stimulation and changes in Epworth Sleepiness Scale scores.
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Registered trials
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