Observational studyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Oral appliance therapy is highly efficacious at reducing sleep apnea-specific hypoxic burden, a metric predictive of cardiovascular morbidity and mortality.
Observational study in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy
Predictive Accuracy of MATRx Plus in Identifying Favorable Candidates for Oral Appliance Therapy
Validation of a Simplified MATRx Plus Theragnostic Sleep Study
Who cites it
5 citing papers in PubMed.
- Increasing reports and shifting categorical trends in adverse events for oral appliances.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Hypoglossal Nerve Stimulation and Hypoxic Burden in Patients With Obstructive Sleep Apnea: A Secondary Analysis of the STAR Trial.JAMA otolaryngology-- head & neck surgery · 2026Article
- Article
- Mandibular advancement devices in severe obstructive sleep apnea: a second-line option that deserves greater recognition.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Efficacy of a Novel Treatment Approach for Obstructive Sleep Apnea.Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesA surrogate metric of obstructive sleep apnea (OSA), sleep apnea-specific hypoxic burden (SASHB), predicts adverse health outcomes associated with the disease and may be useful in assessing therapeutic success. The purpose of this study was to compare outcomes of mandibular protruding oral appliance therapy using apnea-hypopnea index and SASHB in a population with a spectrum of OSA severity.
methodsIndividuals with mild, moderate, or severe OSA (n = 152) were treated with mandibular protruding oral appliance therapy in a prospective observational study. Two-night home sleep apnea tests were used to determine baseline and outcome values of apnea-hypopnea index and SASHB.
resultsMean baseline SASHB differed by OSA severity strata, with 0%, 19%, and 94% percent of study participants with mild, moderate, and severe OSA, respectively, having values greater than 60%min/h. At outcome, these values were reduced to 0%, 0%, and 15%, respectively. For the entire population, therapeutic efficacy was 78% using apnea-hypopnea index < 10 events/h as a response criterion and 95% using SASHB < 60%min/h as the criterion.
conclusionsUsing a risk-predictive outcome surrogate to assess the efficacy of oral appliance therapy yields a substantially higher estimate of therapeutic efficacy of oral appliance therapy, particularly in patients with severe OSA. CLINICAL
trial registrationRegistry: ClinicalTrials.gov; Name: Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy; URL: https://clinicaltrials.gov/study/NCT03011762; Identifier: NCT03011762; Registry: ClinicalTrials.gov; Name: Predictive Accuracy of MATRx Plus in Identifying Favorable Candidates for Oral Appliance Therapy; URL: https://clinicaltrials.gov/study/NCT03217383; Identifier: NCT03217383; Registry: ClinicalTrials.gov; Name: Validation of a Simplified MATRx Plus; URL: https://clinicaltrials.gov/study/NCT03812692; Identifier: NCT03812692. CITATION: Mosca EV, Grosse J, Remmers JE. Oral appliance therapy is highly efficacious at reducing sleep apnea-specific hypoxic burden, a metric predictive of cardiovascular morbidity and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.