Evidence map›Paper›PMID 40123588›Full record

ArticleInternational journal of molecular and cellular medicine2025

Possible Trace of HTLV-1 Virus in Modulation of Cbl-b, ITCH, and PP2A Suppressor Genes.

Atefeh Bahavar, Abdolvahab Moradi, Hamed Mohammadi, Mehdi Norouzi, Sara Khodayar, Sayed-Hamidreza Mozhgani, Alijan Tabarraei

Abstract read
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In one paragraph

Article in International journal of molecular and cellular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Atefeh BahavarDepartment of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Abdolvahab MoradiInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Hamed MohammadiDepartment of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mehdi NorouziDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Sara KhodayarDepartment of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Sayed-Hamidreza MozhganiNon-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Alijan TabarraeiInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For almost 40 years, human T-lymphotropic virus type 1 (HTLV-1) has posed a persistent challenge in managing the major diseases associated with HTLV-1. Intracellular inhibitors are critical regulators of T cell activation, and their function can be influenced by viruses. Because of less studied aspects of HTLV-1 in T cell activation, we evaluated three suppressor genes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and asymptomatic carriers (ACs). Thirty samples were collected from three groups from 10/09/2022 to 03/27/2024. To confirm all the samples, ELISA and PCR tests were done. The isolation of peripheral blood mononuclear cells (PBMCs), RNA extraction, and cDNA synthesis were conducted. Subsequently, the expression of

Indexed as

E3 ligaseHTLV-1protein phosphatase 2suppressor genes

Identifiers

PMID40123588
PMCPMC11927157

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.