ArticlePhysics and imaging in radiation oncology2025
Uncertainty estimation in female pelvic synthetic computed tomography generated from iterative reconstructed cone-beam computed tomography.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: Iterative reconstruction (IR) can be used to improve cone-beam computed tomography (CBCT) image quality and from such iterative reconstructed (iCBCT) images, synthetic CT (sCT) images can be generated to enable accurate dose calculations. The aim of this study was to evaluate the uncertainty in generating sCT from iCBCT using vendor-supplied software for online adaptive radiotherapy. Materials and Methods: Projection data from 20 female pelvic CBCTs were used to reconstruct iCBCT images. The process was repeated with 128 different IR parameter combinations. From these iCBCTs, sCTs were generated. Voxel value variation in the 128 iCBCT and 128 sCT images per patient was quantified by the standard deviation (STD). Additional sub-analysis was performed per parameter category. Results: Generated sCTs had significantly higher maximum STD-values, median of 438 HU, compared to input iCBCT, median of 198 HU, indicating limited robustness to parameter changes. The highest STD-values of sCTs were within bone and soft-tissue compared to air. Variations in sCT numbers were parameter dependent. Scatter correction produced the highest variance in sCTs (median: 358 HU) despite no visible changes in iCBCTs, whereas total variation regularization resulted in the lowest variance in sCTs (median: 233 HU) despite increased iCBCT blurriness. Conclusions: Variations in iCBCT reconstruction parameters affected the CT number representation in the sCT. The sCT variance depended on the parameter category, with subtle iCBCT changes leading to significant density alterations in sCT. Therefore, it is recommended to evaluate both iCBCT and sCT generation, especially when updating software or settings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.