Evidence map›Paper›PMID 40124311›Full record

ArticleOphthalmology science

Evaluating the Preclinical Efficacy of Photobiomodulation in Alleviating Neuropathic Corneal Pain: A Behavioral Study.

Mohd Afzal Khan, Gehan Fatima, Akm Ashiquzzaman, Sang Seong Kim, Hyuksang Kwon, Young Ro Kim, Euiheon Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohd Afzal KhanDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Gehan FatimaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Akm AshiquzzamanDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Sang Seong KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Hyuksang KwonDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Young Ro KimDepartment of Radiology, Harvard Medical School, Boston, Massachusetts.
Euiheon ChungDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Neuropathic corneal pain (NCP) is a debilitating condition characterized by persistent pain due to corneal nerve damage or dysfunction. Millions of individuals and their families endure the significant impact of chronic pain. Effective management strategies are crucial yet limited, prompting the exploration of innovative treatments such as photobiomodulation (PBM). Design: In vivo preclinical therapeutics investigation in mice. Subjects: Thy1-YFP mice. Methods: This study evaluates the efficacy of PBM in treating NCP across 4 animal models: normal control, sham control, pulled nerve, and full transection (FT). Behavioral assessments, including the von Frey test (VFT) for mechanical sensitivity and the eye-wiping test (EWT) for chemical sensitivity, were employed to evaluate the therapeutic impact of PBM till day 56 (D-1, D1, D3, D5, D7, D14, D28, D42, and D56). Main Outcome Measures: Advances in therapeutic approach for NCP through the potential of PBM. Results: Photobiomodulation significantly reduced behavioral manifestations of pain in the pulled nerve model (VFT: no PBM [D1 = 0.043 ± 0.044, D56 = 0.05 ± 0.014] and PBM [D1 = 0.050 ± 0.008 { Conclusions: These outcomes support PBM as a promising nonpharmacologic intervention for NCP; this not only reinforces the potential of PBM in NCP treatment but also provides a foundation for future clinical applications in managing corneal neuropathy. Financial Disclosures: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Behavior testsChronic painInvivoNeuropathic corneal pain (NCP)Photobiomodulation (PBM)

Identifiers

PMID40124311
PMCPMC11930074

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.