Evidence map›Paper›PMID 40124499›Full record

ArticleiScience2025

Genetic modulation of protein expression in rat brain.

Ling Li, Zhiping Wu, Andrea Guarracino, Flavia Villani, Dehui Kong, Ariana Mancieri, Aijun Zhang, Laura Saba, Hao Chen, Hana Brozka and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ling LiDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Andrea GuarracinoDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Flavia VillaniDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Dehui KongDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ariana MancieriDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Aijun ZhangDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Laura SabaDepartment of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA.
Hao ChenDepartment of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Hana BrozkaInstitute of Physiology of the Czech Academy of Sciences, Prague 14200, Czech Republic.
Karel ValesInstitute of Physiology of the Czech Academy of Sciences, Prague 14200, Czech Republic.
Anna N SenkoGenomics of Regeneration of the Central Nervous System, Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany.
Gerd KempermannGenomics of Regeneration of the Central Nervous System, Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany.
Ales StuchlikInstitute of Physiology of the Czech Academy of Sciences, Prague 14200, Czech Republic.
Michal PravenecInstitute of Physiology of the Czech Academy of Sciences, Prague 14200, Czech Republic.
Joseph LechnerDepartment of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pjotr PrinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ramkumar MathurDepartment of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Kai YangDepartment of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Xusheng WangDepartment of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variations in protein expression are implicated in a broad spectrum of common diseases and complex traits but remain less explored compared to mRNA and classical phenotypes. This study systematically analyzed brain proteomes in a rat family using tandem mass tag (TMT)-based quantitative mass spectrometry. We quantified 8,119 proteins across two parental strains (SHR/Olalpcv and BN-Lx/Cub) and 29 HXB/BXH recombinant inbred (RI) strains, identifying 597 proteins with differential expression and 464 proteins linked to

Indexed as

BiochemistryGeneticsNeuroscience

Identifiers

PMID40124499
PMCPMC11930185

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.