Evidence map›Paper›PMID 40125534›Full record

ArticleJournal of Taibah University Medical Sciences2025

Forastero cacao bean extract gel decreases IL-6 positive osteoblasts, osteoclasts, and osteocytes on OIRR model: A primitive study.

Shierin V Fiolita, Firda Q Aini Rasyid, Lilis Nurhalifah, Rudy Joelijanto, Leliana S Devi, Vanda Ramadhani, Happy Harmono, Banun Kusumawardani, Syafika N Fadiyah, Millenieo Martin

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In one paragraph

Article in Journal of Taibah University Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shierin V FiolitaDepartment of Dentistry, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Firda Q Aini RasyidDepartment of Dentistry, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Lilis NurhalifahDepartment of Dentistry, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Rudy JoelijantoDepartment of Orthodontics, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Leliana S DeviDepartment of Orthodontics, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Vanda RamadhaniDepartment of Orthodontics, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Happy HarmonoDepartment of Biomedical Sciences, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Banun KusumawardaniDepartment of Biomedical Sciences, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Syafika N FadiyahDepartment of Dentistry, Faculty of Dentistry, University of Jember, Jember, Indonesia.
Millenieo MartinDepartment of Dentistry, Faculty of Dentistry, University of Jember, Jember, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malocclusion can be corrected with orthodontic treatment to improve function and aesthetics. Orthodontic treatment patients have the potential to produce greater Reactive Oxygen Species (ROS), as evidenced by an increase in the Oxidative Status Index (OSI) a week after treatment. As a result, oxidative stress may induce an imbalance of bone remodeling through intensifying osteoclastogenesis by expressing pro-inflammatory cytokine, namely Interleukin-6 (IL-6). The worst pathological condition that can occur is Orthodontic-Induced Root Resorption (OIRR), a resorptive area on the root that is unwanted from orthodontic treatment. OIRR incidence is reported to be more than 90 % asymptomatic. Using Forastero cacao bean ( Aim: This study aimed to investigate the effect of Forastero cacao bean ( Results: IL-6 positive osteoblasts, osteoclasts, and osteocytes decreased significantly after 8 % Forastero cacao bean extract gel-treated, as seen in T Conclusions: 8 % Forastero cacao bean extract gel decreased IL-6-positive osteoblasts, osteoclasts, and osteocytes in the tension side of the alveolar bone.

Indexed as

Alveolar boneAnti-inflammatoryFlavonoidForastero cacao bean (Theobroma cacao L.) extract gelNF-κBOrthodontic tooth movement

Identifiers

PMID40125534
PMCPMC11925084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.