Evidence map›Paper›PMID 40125555›Full record

ArticleJCI insight2025

Reduced high-density lipoprotein antioxidant function in patients with coronary artery disease and acute coronary syndrome.

Benjamin Sasko, Linda Scharow, Rhea Mueller, Monique Jaensch, Werner Dammermann, Felix S Seibert, Philipp Hillmeister, Ivo Buschmann, Martin Christ, Oliver Ritter and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Benjamin SaskoRuhr-University of Bochum, Medical Department II, Marien Hospital Herne, Bochum, Germany.
Linda ScharowDepartment of Cardiology, University Hospital Ruppin-Brandenburg, Medical School Theodor Fontane, Neuruppin, Germany.
Rhea MuellerDepartment of Cardiology, University Medical Center Brandenburg an der Havel, Medical School Theodor Fontane, Brandenburg an der Havel, Germany.
Monique JaenschDepartment of Cardiology, University Hospital Ruppin-Brandenburg, Medical School Theodor Fontane, Neuruppin, Germany.
Werner DammermannFaculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus - Senftenberg, the (MHB) Theodor Fontane and the University of Potsdam, Germany.
Felix S SeibertMedical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Bochum, Germany.
Philipp HillmeisterFaculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus - Senftenberg, the (MHB) Theodor Fontane and the University of Potsdam, Germany.
Ivo BuschmannFaculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus - Senftenberg, the (MHB) Theodor Fontane and the University of Potsdam, Germany.
Martin ChristDepartment of Cardiology, Knappschaftskrankenhaus Bottrop, Academic Teaching Hospital, University Duisburg-Essen, Germany.
Oliver RitterDepartment of Cardiology, University Medical Center Brandenburg an der Havel, Medical School Theodor Fontane, Brandenburg an der Havel, Germany.
Nazha HamdaniDepartment of Cellular and Translational Physiology, Institute of Physiology, and.
Christian UkenaRuhr-University of Bochum, Medical Department II, Marien Hospital Herne, Bochum, Germany.
Timm H WesthoffMedical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Bochum, Germany.
Theodoros KelesidisDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Nikolaos PagonasDepartment of Cardiology, University Hospital Ruppin-Brandenburg, Medical School Theodor Fontane, Neuruppin, Germany.

Funding

NIAID NIH HHS K08 AI108272NIA NIH HHS R01 AG059502NIA NIH HHS R03 AG059462NIA NIH HHS R43 AG059501
6 · The paper itself

Abstract

resultsParticipants with CAD (n = 723) had 12% higher mean relative levels of nHDLox compared with those with invasively excluded CAD (n = 502, P < 0.001). Patients presenting with symptoms of an ACS had the highest nHDLox values when compared with the elective cohort (median 1.35, IQR 0.97 to 1.85, P < 0.001). In multivariate analysis adjusted for age, sex, body mass index, and hypertension, nHDLox was a strong independent predictor of ACS (P < 0.001) but not of CAD (P > 0.05).

conclusionHDL antioxidant function is reduced in patients with CAD. nHDLox is strongly associated with ACS.

trial registrationGerman Clinical Trials Register DRKS00014037.

fundingBrandenburg Medical School Theodor Fontane, the BIOX Stiftung, and NIH grants R01AG059501 and R03AG059462.

backgroundHigh-density lipoprotein (HDL) function rather than its concentration plays an important role in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to determine whether reduced antioxidant function of HDL is associated with the presence of a stable CAD or acute coronary syndrome (ACS).

methodsHDL function was measured in 2 cohorts: 1225 patients admitted electively for coronary angiography and 196 patients with ACS. A validated cell-free biochemical assay was used to determine reduced HDL antioxidant function, as assessed by increased HDL-lipid peroxide content (HDLox), which was normalized by HDL-C levels and the mean value of a pooled serum control from healthy participants (nHDLox; unitless). Results are expressed as median with interquartile range (IQR).

Indexed as

Acute Coronary SyndromeAntioxidantsCoronary Artery DiseaseLipoproteins, HDLAgedFemaleHumansMaleMiddle AgedRisk FactorsAntioxidantsLipoproteins, HDLAtherosclerosisCardiologyCholesterolInflammationLipoproteinsMetabolism

Identifiers

PMID40125555
PMCPMC11949010

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.