ArticleJournal of cardiovascular electrophysiology2025
Trends in Mortality Related to Atrial Fibrillation and Dementia in Older Adults in the United States: A 2000-2020 Analysis.
Article in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Trends and Disparities in Mortality from Hereditary Ataxia in United States, 2000-2020: A Retrospective Analysis with Projections to 2050.Cerebellum (London, England) · 2026Article
- National Mortality Trends, Disparities, and Forecasted Burden of Atrial Fibrillation and Heart Failure with Underlying Ischemic Heart Disease Among Older Adults in the United States, 1999-2023.Journal of epidemiology and global health · 2026Article
- Trends and Disparities in Dementia Among Older Adults With Coronary Artery Disease, 1999-2023: Insights From the CDC WONDER Database.Brain and behavior · 2025Article
- Sex Differences in Individuals at High Risk of Atrial Fibrillation: A Primary Care Community Cohort Study, 2015-2024.Biomedicines · 2025Article
- Trends and differences in cardiovascular disease and alzheimer's disease-related mortality among older adults in the United States, 1999 to 2023: A CDC WONDER database analysis.American heart journal plus : cardiology research and practice · 2025Article
- Rising burden of cancer and atrial fibrillation-related mortality among adults in the United States, 1999-2019.Heart rhythm O2 · 2025Article
- Coronary artery disease and dementia-related mortality among older adults in the United States from 2000 to 2020.Archives of medical sciences. Atherosclerotic diseases · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAtrial fibrillation (AF) and dementia are increasingly prevalent in aging US populations. Their association raises public health concerns, emphasizing the need to understand mortality trends in older adults. This study examines AF and dementia-related mortality trends from 2000 to 2020.
methodsUsing the CDC WONDER Multiple Cause of Death database, we analyzed death certificates for individuals aged 65 and older, reporting age-adjusted mortality rates (AAMRs) per 100 000 persons. Trends were assessed through annual percent change (APC) analysis via Joinpoint regression, with stratifications by sex, race/ethnicity, urbanization, and Census regions.
resultsA total of 400 103 AF and dementia-related deaths were recorded between 2000 and 2020. The AAMR increased markedly from 25.4 in 2000 to 70.4 in 2020. The overall AAMR showed a steady increase from 2000 to 2018 (APC: +4.2%; 95% CI: 2.5-5.5), with a sharper rise from 2018 to 2020 (APC: +9.5%; 95% CI: 4.5-12.2; p < 0.001). Mortality rates were comparable between men (AAMR: 44.4) and women (AAMR: 43.9). NH White individuals exhibited the highest AAMR (47.0), followed by NH Black (26.6), Hispanic (23.1), and NH Asian/Pacific Islander (18.0) populations. Nonmetropolitan areas had higher AAMRs (48.1) compared to metropolitan areas (43.5). Regionally, the Western US recorded the highest AAMR at 48.2, while state-level disparities showed a nearly threefold difference between the top 90th and bottom 10th percentiles.
conclusionRising AF and dementia-related mortality rates among older adults highlight a need for targeted screening and intervention, particularly for high-risk demographics and underserved regions.
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